Evidence map›Paper›PMID 33711960›Full record

ArticleBMC nephrology2021

Long-term impact of baseline serum uric acid levels on living kidney donors: a retrospective study.

Kosuke Tanaka, Shigeyoshi Yamanaga, Yuji Hidaka, Sho Nishida, Kohei Kinoshita, Akari Kaba, Toshinori Ishizuka, Satoshi Hamanoue, Kenji Okumura, Chiaki Kawabata and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kosuke TanakaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Shigeyoshi YamanagaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan. yamanaga@kumamoto-med.jrc.or.jp.
Yuji HidakaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Sho NishidaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Kohei KinoshitaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Akari KabaDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Toshinori IshizukaDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Satoshi HamanoueDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Kenji OkumuraDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Chiaki KawabataDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Mariko ToyodaDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Akira MiyataDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Masayuki KashimaDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Hiroshi YokomizoDepartment of Surgery, Japanese Red Cross Kumamoto Hospital, 861-8520, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, Japan.
Japanese Red Cross Kumamoto Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function.

methodsThis was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (< 5.5 mg/dl) UA groups. We analyzed the relationship between preoperative UA levels and postoperative estimated glomerular filtration rate (eGFR), as well as adverse events (cardiovascular events and additional prescriptions for hypertension, gout, dyslipidemia, and diabetes mellitus), over 5 years after donation.

resultsIn total, 44 donors experienced 52 adverse events over 5 years. The incidence of adverse events within 5 years was significantly higher in the high UA group than in the low UA group (50% vs. 24%, p = 0.003); this was true even after the exclusion of hyperuricemia-related events (p = 0.047). UA emerged as an independent risk factor for adverse events (p = 0.012). Donors with higher UA levels had lower eGFRs after donation, whereas body mass index, hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol did not have any impact on the eGFR.

conclusionsThe findings suggest that preoperative UA levels should be considered during donor selection and postoperative follow-up.

Indexed as

Donor SelectionKidney TransplantationLiving DonorsAgedFemaleHumansMaleMiddle AgedPreoperative PeriodRetrospective StudiesTime FactorsTreatment OutcomeUric AcidUric AcidAdverse eventsLiving kidney donorsSerum uric acid

Identifiers

PMID33711960
PMCPMC7953616
OpenAlexW3122582857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.