Evidence map›Paper›PMID 33711956›Full record

ArticleBMC pregnancy and childbirth2021

Fertility outcomes in women after controlled ovarian stimulation with gonadotropin releasing hormone agonist long protocol: fresh versus frozen embryo transfer.

Xiaoyan Ding, Jingwei Yang, Lan Li, Na Yang, Ling Lan, Guoning Huang, Hong Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaoyan DingChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Jingwei YangChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Lan LiChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Na YangChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Ling LanChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Guoning HuangChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China.
Hong YeChongqing Key Laboratory of Human Embryo Engineering, Chongqing Clinical Research Center for Reproductive Medicine, Reproductive and Genetics Institute, Chongqing Health Center for Women and Children, 400013, Chongqing, China. yehong1210@163.com.
Chongqing Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlong with progress in embryo cryopreservation, especially the vitrification, freeze all strategy has become more acceptable than ever. Some studies have found comparable or higher live birth rate with frozen embryo transfer (FET) than with fresh embryo transfer(ET)in gonadotropin releasing hormone antagonist (GnRH-ant) protocol. However from our literature research, there have been no reports about live birth rate comparison between fresh ET and FET with gonadotropin releasing hormone agonist (GnRH-a) long protocol. The aim of this study is to retrospectively investigate whether patients benefit from freeze all strategy in GnRH-a protocol using real-world data.

methodsThis is a retrospective cohort study, in which women undergoing fresh ET or FET with GnRH-a long protocol at Chongqing Reproductive and Genetics Institute from January 2016 to December 2018 were evaluated. The primary outcome was live birth rate. The secondary outcomes were implantation rate, clinical pregnancy rate, pregnancy loss and ectopic pregnancy rate.

resultsA total of 7,814 patients met inclusion criteria, implementing 5,216 fresh ET cycles and 2,598 FET cycles, respectively. The demographic characteristics of the patients were significantly different between fresh ET and FET groups, except BMI. After controlling for a broad range of potential confounders including age, infertility duration, BMI, AMH, number of oocytes retrieved and of available embryos, multivariate logistic regression analysis demonstrated that there was no significant difference in clinical pregnancy rate, ectopic pregnancy rate and pregnancy loss rate between two groups (all P > 0.05). However, the implantation rate and live birth rate in fresh ET group were significantly higher than FET group (P < 0.001 and P = 0.012, respectively).

conclusionsUnder GnRH-a long protocol, compared to FET, fresh ET was associated with higher implantation rate and live birth rate in infertile patients that underwent in vitro fertilization (IVF). The freeze all strategy should be individualized and made with caution especially with GnRH-a long protocol.

Indexed as

Embryo TransferFertilization in VitroAdultChinaClinical ProtocolsComparative Effectiveness ResearchCryopreservationFemaleGonadotropin-Releasing HormoneHumansInfertilityOvulation InductionPregnancyPregnancy OutcomePregnancy RateRetrospective StudiesGonadotropin-Releasing HormoneFresh embryo transferFrozen embryo transferGonadotropin releasing hormone agonist long protocolIn vitro fertilizationLive birth rate

Identifiers

PMID33711956
PMCPMC7955631
OpenAlexW3134224205

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.