Evidence map›Paper›PMID 33711953›Full record

ArticleBMC cancer2021

KK-LC-1 may be an effective prognostic biomarker for gastric cancer.

Jun Ji, Jiahui Chen, Anqiang Wang, Wei Zhang, Hongge Ju, Yang Liu, Leping Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jun JiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
Jiahui ChenDepartment of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Anqiang WangDepartment of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Wei ZhangBaotou Medical College, Inner Mongolia University of Science & Technology, Baotou, 014060, Inner Mongolia, China.
Hongge JuBaotou Medical College, Inner Mongolia University of Science & Technology, Baotou, 014060, Inner Mongolia, China.
Yang LiuBaotou Medical College, Inner Mongolia University of Science & Technology, Baotou, 014060, Inner Mongolia, China. liuyang_bt@163.com.
Leping LiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China. lileping@medmail.com.cn.ORCID http://orcid.org/0000-0003-2329-6791
Inner Mongolia University of Science and Technology · CNPeking University · CNShandong University · CN

Funding

Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region NJZZ18184
6 · The paper itself

Abstract

backgroundThe objective of the study was to detect the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC-1) in gastric cancer (GC) specimens and analyse the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis.

methodsAll of the 94 patients in this study were GC patients who underwent surgical resection. KK-LC-1 protein expression in GC tissue was detected by immunohistochemistry. This report applies the histological score (H-score) to evaluate KK-LC-1 expression. To calculate this indicator, the number of positive cells in each section and their staining intensity were converted to corresponding values. The expression of KK-LC-1 in the cytoplasm of cancer and normal tissues was scored to obtain their respective H values. The chi-square test, Kaplan-Meier method and Cox regression were used to analyse the linear association between KK-LC-1 expression and clinicopathological data and prognosis.

resultsIn the cytoplasm, KK-LC-1 expression in tumour tissues was significantly higher than that in normal tissues (P < 0.001). Using the median H-score as the cut-off value, we discovered that GC patients with high levels of KK-LC-1 expression in the cytoplasm had favourable overall survival (OS) (P = 0.016), and this result was statistically significant in the Cox regression analysis. Additionally, a negative correlation was found between KK-LC-1 protein expression and the pathological grade of the tumour (P = 0.036), with significantly more KK-LC-1 protein expression observed in the intestinal type of GC than in the diffuse type (P = 0.008).

conclusionsOur research data showed that KK-LC-1 expression was greater in GC tissues than in normal tissues, and higher KK-LC-1 expression was associated with longer OS of GC patients. KK-LC-1 can be used as a biomarker for a good prognosis in GC patients.

Indexed as

AgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorFemaleFollow-Up StudiesGastrectomyHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm GradingPrognosisRisk AssessmentStomachStomach NeoplasmsAntigens, NeoplasmBiomarkers, TumorCT83 protein, humanBiomarkerGastric cancerKK-LC-1Overall survivalRisk score

Identifiers

PMID33711953
PMCPMC7953676
OpenAlexW3121612616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.