ArticleBMC pregnancy and childbirth2021
Assessing the association between periodontitis and premature birth: a case-control study.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Prediction of preterm and low birth weight risk using a physiology based artificial neural network integrating hematological, dental, and periodontal index markers: a cross sectional study based on machine learning.BMC pregnancy and childbirth · 2026Article
- Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications.Frontiers in immunology · 2026Review
- Brain Structures, Circuits, and Networks Involved in Immune Regulation, Periodontal Health, and Disease.Life (Basel, Switzerland) · 2025Review
- Healthcare workers' perspectives on integrated oral and antenatal health care at public health facilities in southwestern nigeria: a qualitative study.BMC health services research · 2025Article
- The relationship between maternal oral health parameters, inflammatory blood markers, and the evaluation of their effects on preterm low birth weight.BMC pregnancy and childbirth · 2025Article
- Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease.Periodontology 2000 · 2024Review
- Oral health behavior of pregnant women in Nigeria: a scoping review.BMC oral health · 2024Article
- The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth.Medicina (Kaunas, Lithuania) · 2024Article
- The Impact of Periodontal Disease on Preterm Birth and Preeclampsia.Journal of personalized medicine · 2024Review
- Maternal periodontitis as a risk factor for preterm birth: A cross-sectional study.Journal of dental research, dental clinics, dental prospects · 2024Article
- Incorporating basic periodontal screening into antenatal care services provided in Rwanda: A policy brief.F1000Research · 2024Article
- Interleukin 1 beta and its association with the periodontal health of pregnant women.Journal of Taibah University Medical Sciences · 2023Article
- Maternal, obstetric and gynecological factors associated with preterm birth in Rwanda: findings from a national longitudinal study.BMC pregnancy and childbirth · 2023Article
- Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study.Journal of clinical medicine · 2023Article
- The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications.Frontiers in medicine · 2023Review
- A Scoping Review of Preterm Births in Sub-Saharan Africa: Burden, Risk Factors and Outcomes.International journal of environmental research and public health · 2022Article
- The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis.Reproduction (Cambridge, England) · 2022Review
- The Association between Maternal Periodontitis and Preterm Birth: A Case-Control Study in a Low-Resource Setting in Sudan, Africa.Medicina (Kaunas, Lithuania) · 2022Article
- Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies.Frontiers in medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremature delivery is among the leading causes of perinatal mortality and morbidity in developed societies, which is an important obstetrics problem. Maternal periodontitis is a prevalent condition that has been suspected to be associated with adverse pregnancy outcomes such as premature birth. However, there are still conflicting results about this possible relationship, therefore this study was designed to test the association between maternal periodontitis and premature birth. This study also provides information about a new screening tool recommended for use by nurses and midwives to screen for periodontal diseases during antenatal consultations in order to improve the health of mothers and children.
methodsA retrospective case-control study was conducted at 12 health facilities in the Southern Province of Rwanda from February to August, 2018. A total of 555 women in the postpartum period were enrolled in the study. Cases and controls were enrolled in a ratio of 1:2; each enrolled case of preterm birth was followed by 2 unmatched control subjects that were next on the register and who delivered at term gestation. A total of 185 cases of preterm deliveries and 370 controls of term delivery were enrolled in the study. Multivariate regression analysis was used and the independent variables were hierarchically entered in three groups: The first group involved demographic variables that were put in the regression model as Step 1. The second group was made up of other potential risk factors that were placed in the regression model as the second step. Periodontitis was entered in the final regression step, as it was hypothesized as the main predictor variable.
resultsA statistically significant association was found between periodontitis and premature birth. Women who had periodontitis had 6 times the odds of giving birth to premature birth infants compared to women who had no periodontitis (OR: 6.360, 95% CI 3.9, 10.4).
conclusionThe study results indicate that periodontitis is strongly associated with premature birth. Preventive solutions including the use of a periodontitis screening tool for nurses and midwives during antenatal care consultations, are highly recommended.
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