Evidence map›Paper›PMID 33711513›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2021

At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities.

Mark K Greenwald, Tabitha E H Moses, Timothy A Roehrs

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark K GreenwaldDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan. Electronic address: mgreen@med.wayne.edu.
Tabitha E H MosesDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan.
Timothy A RoehrsDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan; Sleep Disorders Center, Henry Ford Health System, Detroit, Michigan.

Funding

Dual-orexin antagonism as a mechanism for improving sleep and drug abstinence in opioid use disorderU01HL150551 · NHLBI · WAYNE STATE UNIVERSITY · PI GREENWALD, MARK K, ROEHRS, TIMOTHY A · 2019 to 2019
$4.0M
Risks for Transition from Therapeutic Hypnotic Use to AbuseR01DA038177 · NIDA · HENRY FORD HEALTH SYSTEM · PI ROEHRS, TIMOTHY A · 2015 to 2019
$2.7M
NHLBI NIH HHS U01 HL150551NIDA NIH HHS R01 DA038177
6 · The paper itself

Abstract

Due to the ongoing opioid epidemic, innovative scientific perspectives and approaches are urgently needed to reduce the unprecedented personal and societal burdens of nonmedical and recreational opioid use. One promising opportunity is to focus on the relationship between sleep deficiency and opioid use. In this review, we examine empirical evidence: (1) at the interface of sleep deficiency and opioid use, including hypothesized bidirectional associations between sleep efficiency and opioid abstinence; (2) as to whether normalization of sleep deficiency might directly or indirectly improve opioid abstinence (and vice versa); and (3) regarding mechanisms that could link improvements in sleep to opioid abstinence. Based on available data, we identify candidate sleep-restorative therapeutic approaches that should be examined in rigorous clinical trials.

Indexed as

Analgesics, OpioidBehavior TherapyBiogenic MonoaminesEndocannabinoidsHumansOpioid EpidemicOpioid-Related DisordersOrexin Receptor AntagonistsPhysical Therapy ModalitiesReceptors, MelatoninSleep DeprivationTranslational Research, BiomedicalAnalgesics, OpioidBiogenic MonoaminesEndocannabinoidsOrexin Receptor AntagonistsReceptors, Melatonin

Identifiers

PMID33711513
PMCPMC8217216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.