Evidence map›Paper›PMID 33711428›Full record

ReviewTrends in cardiovascular medicine2022

Cardiovascular pathophysiology from the cardioneural perspective and its clinical applications.

Amit J Shah, Matthew T Wittbrodt, J Douglas Bremner, Viola Vaccarino

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Amit J ShahDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, CNR 3053, Atlanta, GA 30322, United States; Department of Medicine, Division of Cardiology, Emory University School of Medicine, United States; Atlanta Veterans Affairs Healthcare System, Decatur, GA, United States. Electronic address: ajshah3@emory.edu.
Matthew T WittbrodtDepartment of Psychiatry, Emory University School of Medicine, United States; Department of Anesthesiology, Feinberg School of Medicine, Northwestern University.
J Douglas BremnerAtlanta Veterans Affairs Healthcare System, Decatur, GA, United States; Department of Psychiatry, Emory University School of Medicine, United States.
Viola VaccarinoDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, CNR 3053, Atlanta, GA 30322, United States; Department of Medicine, Division of Cardiology, Emory University School of Medicine, United States.

Funding

Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2010 to 2015
$11.0M
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use DisordersUH3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2023 to 2025
$5.8M
Neural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0M
Mechanisms Linking Depression to Cardiovascular RiskR01HL068630 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2001 to 2010
$4.8M
PTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4M
Sleep Disturbance as a Mechanism for Ischemic Heart Disease in PTSDR01HL136205 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2017 to 2020
$3.1M
Dopamine function, inflammation and connectivity in PTSDR01MH120262 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2020 to 2023
$2.9M
Posttraumatic Stress Disorder and Cardiovascular DiseaseR01AG026255 · NIA · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2007
$2.8M
Mechanisms of Depression in CVDR01HL088726 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2008 to 2012
$2.6M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
CSRD VA I01 CX002331NCRR NIH HHS S10 RR016917NHLBI NIH HHS K23 HL127251NHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL068630NHLBI NIH HHS R01 HL088726NHLBI NIH HHS R01 HL109413NHLBI NIH HHS R01 HL125246NHLBI NIH HHS R01 HL136205NHLBI NIH HHS R03 HL146879NHLBI NIH HHS R21 HL093665NHLBI NIH HHS T32 HL130025NIA NIH HHS R01 AG026255NIDA NIH HHS UG3 DA048502NIDA NIH HHS UH3 DA048502NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH056120NIMH NIH HHS R01 MH120262NIMH NIH HHS T32 MH067547RRD VA I01 RX003418
6 · The paper itself

Abstract

Coronary heart disease and psychological stress factors such as depression are prevalent and associated with high morbidity/mortality; they are also challenging to manage, especially when treated in isolation of each other. Recent advances support an integrated approach to their management that is built on a foundation of an extensive, multi-component network of neurological structures. In this review, we describe this extensive cardioneural network that encompasses the heart, brain, spinal cord, and ganglia throughout the body, and then discuss ambulatory and laboratory-based non-invasive measures of this network that both measure psychological stress and heart disease severity. Lastly, we discuss their potential transformative clinical and public health applications, and also possible cardioneural interventions such as exercise and biofeedback.

Indexed as

Autonomic Nervous SystemHeartBiofeedback, PsychologyExerciseHeart RateHumansAutonomic nervous systemHeart rate variabilityNeurocardiology

Identifiers

PMID33711428
PMCPMC8426431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.