Evidence map›Paper›PMID 33711334›Full record

ReviewMolecular and cellular endocrinology2021

The regulation of RNA metabolism in hormone signaling and breast cancer.

Xiaofei Wang, Da Yang

Open access · greenAbstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaofei WangCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, PA, 15261, USA.
Da YangCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, PA, 15261, USA; UPMC Hillman Cancer Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address: dyang@pitt.edu.
University of Pittsburgh · US

Funding

A novel lncRNA-responsive and xenobiotic receptor-mediated regulation of drug metabolism and dispositionR01CA255196 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YANG, DA · 2021 to 2025
$1.8M
The oncogenic role of EPIC1MYC axis in breast cancerR01CA222274 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YANG, DA · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA222274NCI NIH HHS R01 CA255196
6 · The paper itself

Abstract

As the most frequent women's cancer, breast cancer causes the second most cancer-related death in women worldwide. Majority of the breast cancers are hormone receptor-positive and commonly treated by hormone therapy. Thus, the expression levels of hormone receptors signaling pathways are pivotal in the development and therapy of breast cancer. The expression of hormone receptors signaling pathways is not only regulated at the transcription level but also at the post-transcription level by both proteins and RNAs. In addition to that, the function of hormone receptors can also be regulated by RNAs. In this review, we summarize the roles of RNAs in hormone receptor-positive breast cancer. We introduce how mRNA stability and protein function of genes in hormone receptors signaling pathways are regulated by RNA-binding proteins, miRNAs, and lncRNAs. We believe these proteins and RNAs can be potential therapeutic targets of breast cancer.

Indexed as

Antineoplastic Agents, HormonalBreast NeoplasmsEstrogensFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMCF-7 CellsMicroRNAsNeoplasm ProteinsProgesteroneReceptors, Cell SurfaceRNA, Long NoncodingRNA, MessengerSignal TransductionTestosteroneAntineoplastic Agents, HormonalEstrogensMicroRNAsNeoplasm ProteinsProgesteroneReceptors, Cell SurfaceRNA, Long NoncodingRNA, MessengerTestosteroneBreast cancerHormone receptorHormone therapylncRNAmiRNARNA metabolism

Identifiers

PMID33711334
PMCPMC8262629
OpenAlexW3135749482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.