Trial reportThe Journal of pediatrics2021
Early and Repeated Screening Detects Autism Spectrum Disorder.
Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.JAMA pediatrics · 2023Pooled it
- The Impact of Using Standardized Autism Screening on Referral to Specialist Evaluation for Young Children on the Autism Spectrum: A Cluster-Randomized Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Autism Screening in the First Year and Beyond: Comparison of Multiple Measures.Autism research : official journal of the International Society for Autism Research · 2026Article
- Psychological Impact of Autism Screening on Caregivers.Autism research : official journal of the International Society for Autism Research · 2026Article
- Long-Term Outcomes of Early Autism Spectrum Disorder Screening: Prevalence and Diagnostic Stability in a Decade-Long Cohort from Türkiye.Brain sciences · 2025Article
- What Happens After Autism Screening-Factors That Predict Evaluation Attendance.Journal of autism and developmental disorders · 2025Article
- Caregiver report of infant behavior associated with autism likelihood in first year of life.Pediatric research · 2025Article
- Autistic Traits and Emotion Dysregulation in 5-11-Year-Old Intellectually Able Children With Autism Spectrum Condition: Mediating Role of Emotion Regulation Strategies.Autism research : official journal of the International Society for Autism Research · 2025Article
- Autism screening and diagnostic outcomes among toddlers born preterm.Developmental medicine and child neurology · 2025Article
- Categorizing and identifying preferred interests in autistic toddlers.Autism research : official journal of the International Society for Autism Research · 2024Article
- Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore.Autism : the international journal of research and practice · 2024Article
- Sex differences in early autism screening using the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F).Autism : the international journal of research and practice · 2023Article
- Initial diagnostic impressions of trainees during autism evaluations: High specificity but low sensitivity.Autism research : official journal of the International Society for Autism Research · 2023Article
- Leveraging telehealth to evaluate infants with prodromal autism spectrum disorder characteristics using the telehealth evaluation of development for infants.Autism : the international journal of research and practice · 2022Article
- DSM-5 symptom expression in toddlers.Autism : the international journal of research and practice · 2021Article
- Screening for Autism Spectrum Disorder in Young Children: Still Not Enough Evidence.Journal of primary care & community healthReview
- Comparison of Available Tools to Screen for Autism at 12 and 15 Months.Journal of developmental and behavioral pediatrics : JDBPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate timing and accuracy of early and repeated screening for autism spectrum disorder (ASD) during well-child visits. STUDY
designUsing a longitudinal study design, toddlers (n = 5784) were initially screened at 12 (n = 1504), 15 (n = 1228), or 18 (n = 3052) months during well-child visits, and rescreened at 18, 24, and 36 months. Of those screened, 368 toddlers attended an ASD evaluation after a positive screen and/or a provider concern for ASD at any visit.
resultsScreens initiated at 12 months yielded an ASD diagnosis significantly earlier than at 15 months (P = .003, d = 0.99) and 18 months (P < .001, d = 0.97). Cross-group overall sensitivity of the initial screen was .715 and specificity was .959. Repeat screening improves sensitivity (82.1%), without notably decreasing specificity (all >93.5%). Screening at 18 months resulted in significantly higher positive predictive value than at 12 months (X
conclusionsScreening as early as 12 months effectively identifies many children at risk for ASD. Children screened at 12 months receive a diagnosis of ASD significantly earlier than peers who are first screened at later ages, facilitating earlier intervention. However, as the sensitivity is lower for a single screen, screening needs to be repeated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.