ReviewAdvanced materials (Deerfield Beach, Fla.)2021
In Vitro Mineralization of Collagen.
Review in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 211 citations in OpenAlex.
- BiomimeticBioactive materials · 2026Article
- Enzyme-regulated biomineralization: Biological functions and advanced biomaterials for tissue regeneration.Bioactive materials · 2026Review
- Fish-derived biomaterials in bone tissue engineering: molecular mechanisms and scaffold innovations for enhanced regeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Glucose oxidase-mineralized scaffolds with multiple bioactivities for accelerated diabetic bone regeneration.Journal of nanobiotechnology · 2026Article
- Engineered bone matrix models for understanding breast cancer skeletal metastasis.Cancer metastasis reviews · 2026Review
- Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques.Clinical, cosmetic and investigational dermatology · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- 3D-Printed Multidimensional Bionic Mg-MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects.Advanced healthcare materials · 2025Article
- Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation.Journal of nanobiotechnology · 2025Review
- Targeting collagen to optimize cancer immunotherapy.Experimental hematology & oncology · 2025Review
- Long-Term Culture of Cellular Spheroids in Novel Hydrogel Constructs for ECM Characterization in Bone Models.Materials (Basel, Switzerland) · 2025Article
- Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing.Bioactive materials · 2025Article
- Ultrastructural Aspects of Physiological Mineralization: A Comparative Study in Different Hard Tissues.Biomolecules · 2025Article
- The Effect of Rosavin, a Characteristic Compound ofInternational journal of molecular sciences · 2025Article
- Facile construction of mechanically robust and highly osteogenic materials for bone regeneration.Materials today. Bio · 2025Article
- Mesoscale orchestration of collagen-based hierarchical mineralization.Nature communications · 2025Article
- Matrix vesicle-inspired delivery system based on nanofibrous chitosan microspheres for enhanced bone regeneration.Materials today. Bio · 2025Article
- Application of collagen in bone regeneration.Journal of orthopaedic translation · 2025Review
- Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Advanced glycation end products mediate biomineralization disorder in diabetic bone disease.Cell reports. Medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Collagen mineralization is a biological process in many skeletal elements in the animal kingdom. Examples of these collagen-based skeletons are the siliceous spicules of glass sponges or the intrafibrillar hydroxyapatite platelets in vertebrates. The mineralization of collagen in vitro has gained interest for two reasons: understanding the processes behind bone formation and the synthesis of scaffolds for tissue engineering. In this paper, the efforts toward collagen mineralization in vitro are reviewed. First, general introduction toward collagen type I, the main component of the extracellular matrix in animals, is provided, followed by a brief overview of collagenous skeletons. Then, the in vitro mineralization of collagen is critically reviewed. Due to their biological abundance, hydroxyapatite and silica are the focus of this review. To a much lesser extent, also some efforts with other minerals are outlined. Combining all minerals and the suggested mechanisms for each mineral, a general mechanism for the intrafibrillar mineralization of collagen is proposed. This review concludes with an outlook for further improvement of collagen-based tissue engineering scaffolds.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.