ArticlePLoS pathogens2021
A Phytophthora sojae CRN effector mediates phosphorylation and degradation of plant aquaporin proteins to suppress host immune signaling.
Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- The Small GTPase RHO1 Regulates ROS Homeostasis and Differentially Responds to Pathogens Infection via Interaction With Aquaporin TIP1;1 in Nicotiana.Molecular plant pathology · 2026Article
- Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein RACK1.Molecular plant pathology · 2026Article
- Two Aquaporins Mitigate Growth-Defence Trade-Offs by Facilitating COPlant biotechnology journal · 2026Article
- Puccinia triticina Effector Pt3863 Targets and Subverts TaRLCK176 to Suppress Wheat Resistance to Leaf Rust.Molecular plant pathology · 2026Article
- Comprehensive pan-effectome investigation reveals central effector genes in woody plant pathogen Botryosphaeriaceae.Applied and environmental microbiology · 2026Article
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- EnP1 exploits H2Aub-dependent epigenetic reprogramming to promote microsporidia proliferation in host cells.PLoS pathogens · 2026Article
- Pathogen effector tactics to suppress plant endomembrane system.Frontiers in plant science · 2026Review
- FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses.Nature communications · 2025Article
- Article
- AScience advances · 2025Article
- Genome-wide identification of Morus notabilis Aquaporin gene family and differential expression of plasma membrane intrinsic proteins in response to Ralstonia pseudosolanacearum infection.BMC plant biology · 2025Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Phosphorylation of PIP2;7 by CPK28 or Phytophthora kinase effectors dampens pattern-triggered immunity in Arabidopsis.Plant communications · 2025Article
- The Phytophthora infestans effector Pi05910 suppresses and destabilizes host glycolate oxidase StGOX4 to promote plant susceptibility.Molecular plant pathology · 2024Article
- Mechanisms by Which Exogenous Substances Enhance Plant Salt Tolerance through the Modulation of Ion Membrane Transport and Reactive Oxygen Species Metabolism.Antioxidants (Basel, Switzerland) · 2024Review
- PsAF5 functions as an essential adapter for PsPHB2-mediated mitophagy under ROS stress in Phytophthora sojae.Nature communications · 2024Article
- Whole-genome sequencing of Fusarium spp. causing sugarcane root rot on both chewing cane and sugar-making cane.Stress biology · 2024Article
- Mechanisms of rhizosphere plant-microbe interactions: molecular insights into microbial colonization.Frontiers in plant science · 2024Review
- Genome-Wide Identification and Expression Pattern Profiling of the Aquaporin Gene Family in Papaya (International journal of molecular sciences · 2023Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytophthora genomes encode a myriad of Crinkler (CRN) effectors, some of which contain putative kinase domains. Little is known about the host targets of these kinase-domain-containing CRNs and their infection-promoting mechanisms. Here, we report the host target and functional mechanism of a conserved kinase CRN effector named CRN78 in a notorious oomycete pathogen, Phytophthora sojae. CRN78 promotes Phytophthora capsici infection in Nicotiana benthamiana and enhances P. sojae virulence on the host plant Glycine max by inhibiting plant H2O2 accumulation and immunity-related gene expression. Further investigation reveals that CRN78 interacts with PIP2-family aquaporin proteins including NbPIP2;2 from N. benthamiana and GmPIP2-13 from soybean on the plant plasma membrane, and membrane localization is necessary for virulence of CRN78. Next, CRN78 promotes phosphorylation of NbPIP2;2 or GmPIP2-13 using its kinase domain in vivo, leading to their subsequent protein degradation in a 26S-dependent pathway. Our data also demonstrates that NbPIP2;2 acts as a H2O2 transporter to positively regulate plant immunity and reactive oxygen species (ROS) accumulation. Phylogenetic analysis suggests that the phosphorylation sites of PIP2 proteins and the kinase domains of CRN78 homologs are highly conserved among higher plants and oomycete pathogens, respectively. Therefore, this study elucidates a conserved and novel pathway used by effector proteins to inhibit host cellular defenses by targeting and hijacking phosphorylation of plant aquaporin proteins.
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