Evidence map›Paper›PMID 33710927›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Global REACH 2018: dysfunctional extracellular microvesicles in Andean highlander males with excessive erythrocytosis.

L Madden Brewster, Anthony R Bain, Vinicius P Garcia, Hannah K Fandl, Rachel Stone, Noah M DeSouza, Jared J Greiner, Michael M Tymko, Gustavo A Vizcardo-Galindo, Romulo J Figueroa-Mujica and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

L Madden BrewsterIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Anthony R BainDepartment of Kinesiology, University of Windsor, Windsor, Ontario, Canada.
Vinicius P GarciaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Hannah K FandlIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Rachel StoneDepartment of Kinesiology, University of Windsor, Windsor, Ontario, Canada.
Noah M DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Michael M TymkoUniversity of Alberta, Edmonton, Alberta, Canada.
Gustavo A Vizcardo-GalindoUniversidad Peruana Cayetano Heredia, Lima, Peru.
Romulo J Figueroa-MujicaUniversidad Peruana Cayetano Heredia, Lima, Peru.
Francisco C VillafuerteUniversidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0003-0731-8911
Philip N AinslieFaculty of Health and Social Development, Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
University of Colorado Boulder · USUniversidad Peruana Cayetano Heredia · PEUniversity of British Columbia · CAUniversity of Windsor · CAUniversity of Alberta · CA

Funding

Molecular and Functional Mechanisms of Pediatric Heart FailureR01HL107715 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STAUFFER, BRIAN L · 2012 to 2016
$2.8M
Aging, Exercise and Endothelin-1 Vasoconstrictor ToneR01HL077450 · NHLBI · UNIVERSITY OF COLORADO AT BOULDER · PI DESOUZA, CHRISTOPHER A · 2004 to 2007
$1.4M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL077450HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL107715NHLBI NIH HHS R01 HL077450NHLBI NIH HHS R01 HL107715
6 · The paper itself

Abstract

High altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis, and nitric oxide (NO) production. Twenty-six male residents of Cerro de Pasco, Peru (4,340 m), were studied: 12 highlanders without EE (age: 40 ± 4 yr; BMI: 26.4 ± 1.7; Hb: 17.4 ± 0.5 g/dL, Spo

Indexed as

AcclimatizationAltitudeAdultApoptosisCase-Control StudiesCell-Derived MicroparticlesCells, CulturedHumansHuman Umbilical Vein Endothelial CellsInflammation MediatorsInterleukin-6Interleukin-8MaleNitric OxideNitric Oxide Synthase Type IIIOxidative StressCXCL8 protein, humanIL6 protein, humanInflammation MediatorsInterleukin-6Interleukin-8Nitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanReactive Oxygen SpeciesRELA protein, humanTranscription Factor RelAendothelial cellserythrocytosishighlandersmicrovesicles

Identifiers

PMID33710927
PMCPMC8163655
OpenAlexW3135504416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.