Evidence map›Paper›PMID 33710922›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease.

Charles E Norton, Elizabeth A Grunz-Borgmann, Marcia L Hart, Benjamin W Jones, Craig L Franklin, Erika M Boerman

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Perivascular Adipose Tissue Becomes Pro-Contractile and Remodels in an IL10International journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Role of Sensory Nerves in Pulmonary Fibrosis.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Elizabeth A Grunz-BorgmannDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Marcia L HartDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri.
Benjamin W JonesDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Craig L FranklinDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri.
Erika M BoermanDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0001-8103-3485
University of Missouri · US

Funding

The Mutant Mouse Resource and Research Center at the University of Missouri - ResourceU42OD010918 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI James Amos-Landgraf · 2012 to 2026
$25.1M
Postdoctoral Training in Comparative MedicineT32OD011126 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda, Aaron Ericsson · 2012 to 2026
$3.4M
Role of sensory nerves in perivascular inflammation and vasomotor dysfunction with inflammatory bowel diseaseR01HL157038 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BOERMAN, ERIKA MARY · 2021 to 2025
$1.9M
Role of perivascular nerves and vascular dysfunction in inflammatory bowel diseaseR00HL129196 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BOERMAN, ERIKA MARY · 2018 to 2020
$746k
Role of perivascular nerves and vascular dysfunction in inflammatory bowel diseaseK99HL129196 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BOERMAN, ERIKA MARY · 2016 to 2017
$185k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K99HL129196HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL129196NHLBI NIH HHS K99 HL129196NHLBI NIH HHS R00 HL129196NHLBI NIH HHS R01 HL157038NIH HHS T32 OD011126NIH HHS U42 OD010918
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-related deficits in perivascular sensory nerve function and vascular neurotransmitter signaling. In MAs from an interleukin-10 knockout (IL-10

Indexed as

Splanchnic CirculationAnimalsCalcitonin Gene-Related PeptideDisease Models, AnimalFemaleHelicobacter hepaticusInflammatory Bowel DiseasesInterleukin-10MaleMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutReceptors, Calcitonin Gene-Related PeptideReceptors, Neurokinin-1Sensory Receptor CellsCalcitonin Gene-Related PeptideIL10 protein, mouseInterleukin-10Receptors, Calcitonin Gene-Related PeptideReceptors, Neurokinin-1Substance Padventitiacalcitonin gene-related peptideinflammationsubstance Psympathetic nervesvasodilation

Identifiers

PMID33710922
PMCPMC8163646
OpenAlexW3134025419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.