Evidence map›Paper›PMID 33710906›Full record

ArticleOrganic letters2021

Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction.

Samantha L Kraus, Sean P Ross, Matthew S Sigman

Abstract read
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In one paragraph

Article in Organic letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samantha L KrausDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.
Sean P RossDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.
Matthew S SigmanDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-5746-8830

Funding

Pd-Catalyzed Olefin Functionalization Reactions for Organic SynthesisR01GM063540 · NIGMS · UNIVERSITY OF UTAH · PI SIGMAN, MATTHEW S · 2002 to 2019
$5.3M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR017539 · NCRR · UNIVERSITY OF UTAH · PI PUGMIRE, RONALD J · 2003 to 2003
$3.8M
Data Science Guided Organic Reaction DevelopmentR35GM136271 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MATTHEW S SIGMAN · 2020 to 2026
$3.5M
A 500MHz NMR Spectrometer with AutomationS10OD025241 · OD · UNIVERSITY OF UTAH · PI FLYNN, PETER F · 2018 to 2018
$600k
The Pd-catalyzed intermolecular enantioselective aza-Heck reactionF32GM128354 · NIGMS · UNIVERSITY OF UTAH · PI ROSS, SEAN P · 2019 to 2021
$149k
NCRR NIH HHS C06 RR017539NIGMS NIH HHS F32 GM128354NIGMS NIH HHS R01 GM063540NIGMS NIH HHS R35 GM136271NIH HHS S10 OD025241
6 · The paper itself

Abstract

The redox-relay Heck reaction is a powerful method for the construction of enantioenriched quaternary stereocenters remote from existing functional groups. However, there has been little success in the design of site-selective alkene functionalization based on these methods. Herein, we show that experimentally determined rates can be used to train a multivariate linear regression model capable of predicting the rate of a specific relay Heck reaction, allowing for the site-selective functionalization of diene substrates.

Indexed as

AlkenesCatalysisMolecular StructureOxidation-ReductionStereoisomerismAlkenes

Identifiers

PMID33710906
PMCPMC8026703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.