Evidence map›Paper›PMID 33710874›Full record

ArticleBioconjugate chemistry2021

A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability.

Calise Bahou, Peter A Szijj, Richard J Spears, Archie Wall, Faiza Javaid, Afrah Sattikar, Elizabeth A Love, James R Baker, Vijay Chudasama

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The Nitrile Bis-Thiol Bioconjugation Reaction.Journal of the American Chemical Society · 2024
    Article
  5. Article
  6. Crystal structure of (Acta crystallographica. Section E, Crystallographic communications · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Calise BahouDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.
Peter A SzijjDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.
Richard J SpearsDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.
Archie WallDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.
Faiza JavaidDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.
Afrah SattikarLifeArc, Accelerator Building, SBC Open Innovation Campus, SG1 2FX, Stevenage, United Kingdom.
Elizabeth A LoveLifeArc, Accelerator Building, SBC Open Innovation Campus, SG1 2FX, Stevenage, United Kingdom.
James R BakerDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.ORCID 0000-0002-7223-2279
Vijay ChudasamaDepartment of Chemistry, University College London, 20 Gordon Street, WC1H OAJ, London, United Kingdom.ORCID 0000-0002-8876-3285

Funding

Wellcome Trust
6 · The paper itself

Abstract

Linkers that enable the site-selective synthesis of chemically modified proteins are of great interest to the field of chemical biology. Homogenous bioconjugates often show advantageous pharmacokinetic profiles and consequently increased efficacy

Indexed as

CysteineHydrolysisSulfhydryl CompoundsCysteineSulfhydryl Compounds

Identifiers

PMID33710874
PMCPMC8154211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.