ArticleJBRA assisted reproduction2021
Overweight and obesity significantly reduce pregnancy, implantation, and live birth rates in women undergoing In Vitro Fertilization procedures.
Article in JBRA assisted reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia.Biomedicines · 2026Review
- Risk factors and treatment strategies for live birth in women with high BMI undergoing ART.BMC medicine · 2026Article
- The Effects of Bariatric Surgery on Female Fertility: A Narrative Review.International journal of molecular sciences · 2026Review
- A multifactorial analysis of in vitro fertilization outcomes.Reproduction & fertility · 2026Article
- Semaglutide and human reproduction: caution at the intersection of energy balance, ovarian function, and follicular development.Reproductive biology and endocrinology : RB&E · 2025Review
- Article
- Development of a single-center predictive model for conventional in vitro fertilization outcomes excluding total fertilization failure: implications for protocol selection.Journal of ovarian research · 2025Article
- The relevance of female overweight in infertility treatment: a position statement of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2025Article
- Impact of obesity on follicular fluid lipid composition and IVF/ICSI outcomes in Korean women: A lipidomic study.PloS one · 2025Article
- Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types.Life (Basel, Switzerland) · 2024Article
- The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation.The Journal of clinical endocrinology and metabolism · 2024Article
- Pregnancy following assisted reproductive technology in morbidly obese patients: assessment of feto-maternal outcomes.Journal of assisted reproduction and genetics · 2024Article
- Pre-pregnancy obesity is not associated with poor outcomes in fresh transfer in vitro fertilization cycles: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Association between obesity and fecundity in patients undergoing intrauterine insemination.F&S reports · 2023Article
- Article
- Influence of climatic conditions in the mesothermal climate area on pregnancies following elective fresh single blastocyst transfer.Journal of assisted reproduction and genetics · 2022Article
- Donor sperm recipients: fertility treatments, trends, and pregnancy outcomes.Journal of assisted reproduction and genetics · 2022Article
- Female obesity and infertility: outcomes and regulatory guidance.Acta bio-medica : Atenei Parmensis · 2022Article
- The fatty acid composition in follicles is related to the developmental potential of oocytes up to the blastocyst stage: a single-centre cohort study.Reproductive biology and endocrinology : RB&E · 2022Article
- The predictive value of preoperative luteinizing hormone to follicle stimulating hormone ratio for ovulation abnormalities recovery after laparoscopic sleeve gastrectomy: A prospective cohort study.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to evaluate the effects of overweight and obesity on fertility outcomes in IVF procedures.
methodsThis was a retrospective and nonrandomized study that included 191 IVF/ICSI cycles using non-donor oocytes performed between July 2016 and December 2018 that were allocated according to Body Mass Index (BMI) in three groups: Normal group: 18.5-24.9 (n=67 women), Overweight group: 25.0-29.9 (n=86 women) and Obesity group: ≥30.0 (n=38 women). We compared fertilization rates, embryo quality at day 3, development and quality of blastocyst, pregnancy rates, implantation rates, and live birth rates.
resultsPatients from all groups had similar stimulation days, but those women with overweight and obesity used more hormones compared to women with normal weight (p<0.05). Fertilization rates, zygotes that underwent cleavage and good-quality embryos at Day 3 were similar between the three evaluated groups. The groups of overweight and obesity had embryos at Day 3 with significantly less cells, compared to those from the normal group (p<0.05). The blastocyst development rate was significantly lower in women with overweight and obesity compared to women with normal BMI (p<0.05); but, the percentages of good blastocysts were similar in all studied patients. Pregnancy, implantation and live birth rates were significantly lower in the group of women with overweight and obesity, compared to those women with normal weight (p<0.05). Obese women had significantly more miscarriages compared to those in the other groups (p<0.05).
conclusionsOur data shows that an increased BMI affects embryo development and significantly reduces the pregnancy, implantation and live birth rates.
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