Evidence map›Paper›PMID 33710777›Full record

ArticleJournal of cellular and molecular medicine2021

Exercise-induced peptide EIP-22 protect myocardial from ischaemia/reperfusion injury via activating JAK2/STAT3 signalling pathway.

Li Zhang, Xuejun Wang, Hao Zhang, Mengwen Feng, Jingjing Ding, Bing Zhang, Zijie Cheng, Lingmei Qian

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li ZhangDepartment of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuejun WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hao ZhangDepartment of Internal Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Mengwen FengDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jingjing DingDepartment of General Practice, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bing ZhangHongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zijie ChengDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lingmei QianDepartment of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5603-3886

Funding

Key Clinical Frontier Technology Project of Department of Science and Technology of Jiangsu Provincial NO. BE2019752National Natural Science Foundation of China 81570209National Natural Science Foundation of China 81873540
6 · The paper itself

Abstract

Recent studies have revealed that exercise has myocardial protective effects, but the exact mechanism remains unclear. Studies have increasingly found that peptides play a protective role in myocardial ischaemia-reperfusion (I/R) injury. However, little is known about the role of exercise-induced peptides in myocardial I/R injury. To elucidate the effect of exercise-induced peptide EIP-22 in myocardial I/R injury, we first determined the effect of EIP-22 on hypoxia/reperfusion (H/R)- or H

Indexed as

AnimalsApoptosisCells, CulturedCell SurvivalDisease Models, AnimalJanus Kinase 2L-Lactate DehydrogenaseMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMyocardial Reperfusion InjuryMyocytes, CardiacPeptidesRatsRats, Sprague-Dawleyalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamideJak2 protein, mouseJanus Kinase 2L-Lactate DehydrogenasePeptidesReactive Oxygen SpeciesStat3 protein, mouseSTAT3 Transcription FactorTyrphostinsEIP-22JAK2/STAT3myocardial I/Rpeptide

Identifiers

PMID33710777
PMCPMC8034444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.