ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Cardiovascular risk and midlife cognitive decline in the Study of Women's Health Across the Nation.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Is hypertension negatively associated with memory performance in women during climacteric? A systematic review.BMC women's health · 2025Pooled it
- Risk factors for hospital-acquired pneumonia in hip fracture patients: A systematic review and meta-analysis.Medicine · 2024Pooled it
- Risk factors for hospital-acquired pneumonia in hip fracture patients: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- Systematic analysis of associations between obesity and memory decline.GeroScience · 2026Article
- Longitudinal association of change in physical activity and cognitive performance in midlife women: Study of women's health across the nation.Preventive medicine · 2025Article
- Early menopause is associated with reduced global brain activity.bioRxiv : the preprint server for biology · 2025Article
- Temporal patterns of cognitive decline after hypertension onset among middle-aged and older adults in China.Scientific reports · 2025Article
- Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exposure to neighborhood concentrated poverty is associated with faster decline in episodic memory among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lifetime history of gestational diabetes and cognitive function in parous women in midlife.Diabetologia · 2025Article
- The Association Between Hypothyroidism and Cognitive Function Change in Women across the Menopause Transition: The Study of Women's Health Across the Nation.Thyroid : official journal of the American Thyroid Association · 2024Article
- Food Intake, Source, and Planning and Shopping Behavior Differences Among Hispanic, White, Black, and Asian Females.Journal of racial and ethnic health disparities · 2024Article
- Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study.Alzheimer's research & therapy · 2024Article
- Cardiovascular Health, Race, and Decline in Cognitive Function in Midlife Women: The Study of Women's Health Across the Nation.Journal of the American Heart Association · 2024Article
- Blood-based biomarkers for Alzheimer's disease and cognitive function from mid- to late life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Relation Between Arterial Hypertension and Cognitive Impairment: A Literature Review.Cureus · 2024Review
- Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- The quantity and quality of cardiovascular fat at mid-life and future cognitive performance among women: The SWAN cardiovascular fat ancillary study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Blood Pressure and Vascular Cognitive Impairment.Stroke · 2022Review
- Cardiometabolic disease, cognitive decline, and brain structure in middle and older age.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
introductionCardiovascular risk factors in midlife have been linked to late life risk for Alzheimer's disease and related dementias (ADRD). The relation of vascular risk factors on cognitive decline within midlife has been less studied.
methodsUsing data from the Study of Women's Health Across the Nation, we examined associations of midlife hypertension, elevated lipid levels, diabetes, fasting glucose, central adiposity, and Framingham heart age with rates of cognitive decline in women who completed multiple cognitive assessments of processing speed, and working and verbal memory during midlife.
resultsDiabetes, elevated fasting glucose, central obesity, and heart age greater than chronological age were associated with rate of decline in processing speed during midlife. Vascular risk factors were not related to rate of decline in working or verbal memory. DISCUSSION: Midlife may be a critical period for intervening on cardiovascular risk factors to prevent or delay later life cognitive impairment and ADRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.