ReviewJournal of neuroendocrinology2021
Central actions of insulin during pregnancy and lactation.
Review in Journal of neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Automated insulin delivery in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis.Acta diabetologica · 2025Pooled it
- Reduced melanocortin tone modulates feeding during pregnancy in mice.Nature communications · 2026Article
- Neuroendocrine crosstalk between sex and metabolic hormones: mechanisms and implications across the female reproductive spectrum.Discover endocrinology and metabolism · 2026Review
- Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation.Development, growth & differentiation · 2026Review
- Mapping O-linked glycosylation in the rat hypothalamus in pregnancy and lactation.Journal of neuroendocrinology · 2025Article
- Impact of Maternal Overweight and Obesity on Adipokines During Pregnancy and Lactation.International journal of molecular sciences · 2025Review
- Review
- Gut Health for Two: the Critical Role of Probiotics and Prebiotics in Pregnancy and Lactation.Current nutrition reports · 2025Review
- Sweetened beverage intake across moderate intake range is not associated with pregnancy-related weight change or biomarkers of glycemic control.Nutrition research (New York, N.Y.) · 2025Observational
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESIMetabolites · 2025Article
- Dietary Sugar and Saturated Fat Consumption Associated with the Gastrointestinal Microbiome during Pregnancy.The Journal of nutrition · 2024Observational
- Investigation of Relationships between Intakes of Human Milk Total Lipids and Metabolic Hormones and Infant Sex and Body Composition.Nutrients · 2024Article
- Variations in Blood Copper and Possible Mechanisms During Pregnancy.Biological trace element research · 2024Review
- The Role of the Glycemic Index and Glycemic Load in the Dietary Approach of Gestational Diabetes Mellitus.Nutrients · 2024Review
- Maternal nutrient metabolism in the liver during pregnancy.Frontiers in endocrinology · 2024Review
- Exploring the potential roles of apelin, visfatin, and irisin in energy regulation in farm animals: an overview.Frontiers in veterinary science · 2024Review
- The impact of glycosylated hemoglobin and 75-g oral glucose tolerance test glucose levels on birthweight percentile.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain.iScience · 2023Article
- Metabolic and feeding adjustments during pregnancy.Nature reviews. Endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Pregnancy and lactation are highly metabolically demanding states. Maternal glucose is a key fuel source for the growth and development of the fetus, as well as for the production of milk during lactation. Hence, the maternal body undergoes major adaptations in the systems regulating glucose homeostasis to cope with the increased demand for glucose. As part of these changes, insulin levels are elevated during pregnancy and lower in lactation. The increased insulin secretion during pregnancy plays a vital role in the periphery; however, the potential effects of increased insulin action in the brain have not been widely investigated. In this review, we consider the impact of pregnancy on brain access and brain levels of insulin. Moreover, we explore the hypothesis that pregnancy is associated with site-specific central insulin resistance that is adaptive, allowing for the increases in peripheral insulin secretion without the consequences of increased central and peripheral insulin functions, such as to stimulate glucose uptake into maternal tissues or to inhibit food intake. Conversely, the loss of central insulin actions may impair other functions, such as insulin control of the autonomic nervous system. The potential role of low insulin in facilitating adaptive responses to lactation, such as hyperphagia and suppression of reproductive function, are also discussed. We end the review with a list of key research questions requiring resolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.