Evidence map›Paper›PMID 33710641›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A

Leigh A Stoddart, Laura E Kilpatrick, Ross Corriden, Barrie Kellam, Stephen J Briddon, Stephen J Hill

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Species dependence of APurinergic signalling · 2023
    Review
  2. Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine AFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Leigh A StoddartCell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-4469-0600
Laura E KilpatrickCell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0001-6331-5606
Ross CorridenCell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.
Barrie KellamCentre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
Stephen J BriddonCell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0001-8514-0827
Stephen J HillCell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-4424-239X
University of Nottingham · GB

Funding

Medical Research Council G0800006Medical Research Council MR/N020081/1Medical Research Council (MRC) G0800006Medical Research Council (MRC) MR/N020081/1
6 · The paper itself

Abstract

Organization of G protein-coupled receptors at the plasma membrane has been the focus of much recent attention. Advanced microscopy techniques have shown that these receptors can be localized to discrete microdomains and reorganization upon ligand activation is crucial in orchestrating their signaling. Here, we have compared the membrane organization and downstream signaling of a mutant (R108A, R3.50A) of the adenosine A

Indexed as

AdenosineAdenosine A3 Receptor AgonistsAnimalsArrestinBoron CompoundsCHO CellsCricetulusGene Expression RegulationGTP-Binding ProteinsMutationProtein BindingReceptor, Adenosine A3ABEA-X-BY630AdenosineAdenosine A3 Receptor AgonistsArrestinBoron CompoundsGTP-Binding ProteinsReceptor, Adenosine A3adenosine A3 receptorfluorescence correlation spectroscopyG protein-coupled receptorinternalizationmembrane organizationβ-arrestin

Identifiers

PMID33710641
PMCPMC9328438
OpenAlexW3133864617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.