Evidence map›Paper›PMID 33710393›Full record

ArticleArchives of gynecology and obstetrics2021

Modern day screening for Lynch syndrome in endometrial cancer: the KEM experience.

Nina Pauly, Thaïs Baert, Rita Schmutzler, Andreas du Bois, Stephanie Schneider, Kerstin Rhiem, Birgid Schömig-Markiefka, Janna Siemanowski, Sebastian Heikaus, Alexander Traut and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Instability in the Penta-C and Penta-D Loci in Microsatellite-Unstable Endometrial Cancer.International journal of environmental research and public health · 2025
    Article
  2. Article
  3. Immune checkpoint inhibitors: here to stay.Translational cancer research · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Nina PaulyDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany. n.pauly@kem-med.com.ORCID http://orcid.org/0000-0003-1726-8997
Thaïs BaertDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Rita SchmutzlerCenter for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany.
Andreas du BoisDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Stephanie SchneiderDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Kerstin RhiemCenter for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany.
Birgid Schömig-MarkiefkaInstitute of Pathology, University Hospital Cologne, Cologne, Germany.
Janna SiemanowskiInstitute of Pathology, University Hospital Cologne, Cologne, Germany.
Sebastian HeikausCenter for Pathology, Kliniken Essen-Mitte, Essen, Germany.
Alexander TrautDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Sonia PraderDepartment of Gynecology, Hospital Brixen, Brixen, Südtirol, Italy.
Sarah EhmannDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Beyhan AtasevenDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Henricistrasse 92, 45136, Essen, Germany.
Kliniken Essen-Mitte · DEUniversity Hospital Cologne · DEHumboldt-Universität zu Berlin · DEKrankenhaus Brixen · ITLMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCurrent guidelines for Lynch syndrome detection in endometrial cancer (EC) patients rely either on risk evaluation, based on personal/family history, or detection of mismatch repair (MMR) deficiency on tumor tissue. We present a combined screening algorithm for Lynch syndrome.

methodsIn this study, 213 consecutive patients treated for EC at Kliniken Essen-Mitte between 2014 and 2018 were included. Personal/family history was evaluated by the Amsterdam II, revised Bethesda/German-DKG criteria and prediction model PREMM

resultsBased on personal/family history 2/213 (Amsterdam II), 31/213 (revised Bethesda/German-DKG) and 149/213 (PREMM

conclusionGeneral MMR assessment is a feasible strategy to improve the detection of Lynch Syndrome in patients with EC.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsDNA MethylationDNA Mismatch RepairEarly Detection of CancerFemaleHumansMutL Protein Homolog 1MutL Protein Homolog 1DNA mismatch repairEndometrial cancerLynch syndromeMLH1 hypermethylation

Identifiers

PMID33710393
OpenAlexW3134137902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.