ReviewApplied microbiology and biotechnology2021
An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.
Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Evolution of Methods for the Oxidation of Primary Alcohols to Carboxylic Acids: From Metal Oxides to Biocatalysis.JACS Au · 2026Review
- Vitamin BACS central science · 2025Article
- Enzyme engineering of cytochrome P450 RosC provides mechanistic insights into factors controlling iterative oxidation.Applied microbiology and biotechnology · 2025Article
- In Vitro Inhibitory Effects and Molecular Mechanism of Four Theaflavins on Isozymes of CYP450 and UGTs.Foods (Basel, Switzerland) · 2025Article
- Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis.PloS one · 2025Article
- Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(spACS central science · 2023Article
- Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450.Journal of industrial microbiology & biotechnology · 2022Article
- Article
- Enzymatic synthesis of fluorinated compounds.Applied microbiology and biotechnology · 2021Review
- The "beauty in the beast"-the multiple uses of Priestia megaterium in biotechnology.Applied microbiology and biotechnology · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cytochrome P450 enzymes (P450s) are one of the major factors responsible for the diversity of metabolites produced through many biosynthetic and biodegradative processes in actinomycetes. P450s typically catalyze a single oxidative modification; however, several P450s have been identified with the unique ability to iteratively oxidize the same-site of the substrate. These P450s are capable of forming diverse compounds that affect biological processes, including alcohols, ketones, aldehydes, and carboxylic acids. Although further structural and functional studies are needed to elucidate the mechanisms that allow multistep oxidative modification, recent studies have revealed the enzymatic properties and reaction mechanisms of these P450s. This mini-review covers the current knowledge of P450s that catalyze the multistep oxidation reactions and contribute to the production of a wide variety of metabolites by selected actinomycete strains, along with insights into their application and utility. Understanding the characteristics of these remarkable enzymes will facilitate their utilization in biotechnological applications to create biologically active and other high-value compounds. KEY POINTS: • The multistep oxidation by P450s plays a key role in the diversity of metabolites. • The mechanisms that enable P450s to catalyze iterative oxidation remains unknown. • The effective use of P450s that iteratively oxidize the same-site is discussed.
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