ArticleBrain : a journal of neurology2021
Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic social cognition in schizophrenia.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Intersubject correlation as a predictor of attention: a systematic review.BMC psychology · 2025Pooled it
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- Article
- Multivariate relationships between social cognitive performance and functional connectivity during task and rest across schizophrenia spectrum disorders and healthy controls.Molecular psychiatry · 2026Article
- Linking subjective experience of anxiety to brain function using natural language processing.Social cognitive and affective neuroscience · 2026Article
- Trait psychoticism is associated with greater intersubject neural dissimilarity during naturalistic social movie viewing.Scientific reports · 2026Article
- Cognitive dysfunction in schizophrenia: association with peripheral blood inflammatory signatures.BMC psychiatry · 2025Article
- Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.Brain : a journal of neurology · 2025Article
- Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task.Schizophrenia bulletin · 2025Article
- Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences.Current topics in behavioral neurosciences · 2025Review
- Altered neural response to social awkwardness in schizophrenia spectrum disorders.Social cognitive and affective neuroscience · 2024Article
- Naturalistic drug cue reactivity in heroin use disorder: orbitofrontal synchronization as a marker of craving and recovery.medRxiv : the preprint server for health sciences · 2024Article
- Exploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles.Schizophrenia (Heidelberg, Germany) · 2024Article
- Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry.Advances in neurobiology · 2024Review
- The Road Not Taken: Disconnection of a Human-Unique Cortical Pathway Underlying Naturalistic Social Perception in Schizophrenia.Biological psychiatry global open science · 2023Article
- Multiscale Analysis to Explore Neural Bases of Clinically Relevant Cognitive Processes.Biological psychiatry global open science · 2023Article
- Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment.Alzheimer's research & therapy · 2023Article
- Inter-subject correlations of EEG reflect subjective arousal and acoustic features of music.Frontiers in human neuroscience · 2023Article
- The Transdiagnostic Relevance of Self-Other Distinction to Psychiatry Spans Emotional, Cognitive and Motor Domains.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 1 country.
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Abstract
Schizophrenia is associated with marked impairments in social cognition. However, the neural correlates of these deficits remain unclear. Here we use naturalistic stimuli to examine the role of the right temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS)-an integrative hub for the cortical networks pertinent to the understanding complex social situations-in social inference, a key component of social cognition, in schizophrenia. Twenty-seven schizophrenia participants and 21 healthy control subjects watched a clip of the film The Good, the Bad and the Ugly while high resolution multiband functional MRI images were collected. We used inter-subject correlation to measure the evoked activity, which we then compared to social cognition as measured by The Awareness of Social Inference Test (TASIT). We also compared between groups the TPJ-pSTS blood oxygen level-dependent activity (i) relationship with the motion content in the film; (ii) synchronization with other cortical areas involved in the viewing of the movie; and (iii) relationship with the frequency of saccades made during the movie. Activation deficits were greatest in middle TPJ (TPJm) and correlated significantly with impaired TASIT performance across groups. Follow-up analyses of the TPJ-pSTS revealed decreased synchronization with other cortical areas, decreased correlation with the motion content of the movie, and decreased correlation with the saccades made during the movie. The functional impairment of the TPJm, a hub area in the middle of the TPJ-pSTS, predicts deficits in social inference in schizophrenia participants by disrupting the integration of visual motion processing into the TPJ. This disrupted integration then affects the use of the TPJ to guide saccades during the visual scanning of the movie clip. These findings suggest that the TPJ may be a treatment target for improving deficits in a key component of social cognition in schizophrenia participants.
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