ArticleSoft matter2021
Topological defects of integer charge in cell monolayers.
Article in Soft matter, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 2 citations in OpenAlex.
- Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts.Nature materials · 2026Article
- A minimal mechanically consistent model of smoothly dividing disk-shaped cells.NPJ systems biology and applications · 2026Article
- Actuation of Cell Layers in Three Dimensions.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Capturing nematic order on tissue surfaces of arbitrary geometry.Nature communications · 2025Article
- Integer topological defects offer a methodology to quantify and classify active cell monolayers.Nature communications · 2025Article
- Active Nematics Reinforce the Ratchet Flow in Dense Environments Without Jamming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Machine learning topological defects in confluent tissues.Biophysical reports · 2024Article
- Improvement of Intracellular Interactions through Liquid Crystalline Elastomer Scaffolds by the Alteration of Topology.ACS omega · 2023Article
- Migration and division in cell monolayers on substrates with topological defects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers.Journal of the Royal Society, Interface · 2023Article
- Dominant geometrical factors of collective cell migration in flexible 3D gelatin tube structures.Biophysical reports · 2022Article
- Optimal transport and control of active drops.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integer topological defects organize stresses driving tissue morphogenesis.Nature materials · 2022Article
- Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues.Biophysics reviews · 2022Review
- Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation.Bioengineering (Basel, Switzerland) · 2021Review
- Topological defects promote layer formation inNature physics · 2021Article
- Design of nematic liquid crystals to control microscale dynamics.Liquid crystals reviews · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many cell types spontaneously order like nematic liquid crystals, and, as such, they form topological defects, which influence the cell organization. While defects with topological charge ±1/2 are common in cell monolayers, defects with charge ±1, which are thought to be relevant in the formation of protrusions in living systems, are more elusive. We use topographical patterns to impose topological charge of ±1 in controlled locations in cell monolayers. We study two types of cells, 3T6 fibroblasts and EpH-4 epithelial cells, and we compare their behavior on such patterns, characterizing the degree of alignment, the cell density near the defects, and their behavior at the defect core. We observe density variation in the 3T6 monolayers near both types of defects over the same length-scale. By choosing appropriate geometrical parameters of our topographical features, we identify a new behavior of 3T6 cells near the defects with topological charge +1, leading to a change in the cells' preferred shape. Our strategy allows a fine control of cell alignment near defects as a platform to study liquid crystalline properties of cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.