Evidence map›Paper›PMID 33709843›Full record

ArticleDrug delivery2021

Precise engineering of cetuximab encapsulated gadollium nanoassemblies:

Ming Qi, Shufeng Gao, Sihui Nie, Ke Wang, Lingling Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ming QiUltrasound Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Shufeng GaoFunctional Division, Jinzhou Yixian People's Hospital, Jinzhou, China.
Sihui NieUltrasound Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Ke WangUltrasound Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Lingling GuoUltrasound Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Jinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the formulation of nanoassemblies (NAs) comprising C225 conjugates Gd-PFH-NAs (C-Gd-PFH-NAs) for low-intensity focused ultrasound diagnosis ablation of thyroid cancer. C-Gd-PFH-NAs showed excellent stability in water, phosphate-buffered saline (PBS), and 20% rat serum. Transmission electron microscopy (TEM) images also revealed the effective construction of C-Gd-PFH-NAs as common spherical assemblies. The incubation of C625 thyroid carcinoma with C-Gd-PFH-NAs triggers apoptosis, as confirmed by flow cytometry analysis. The C-Gd-PFH-NAs exhibited antitumor efficacy in human thyroid carcinoma xenografts, where histopathological results further confirmed these outcomes. Furthermore, we were able to use low-intensity focused ultrasound diagnosis imaging (LIFUS) to examine the efficiency of C-Gd-PFH-NAs in thyroid carcinoma

Indexed as

AnimalsAntineoplastic Agents, ImmunologicalApoptosisCell Line, TumorCetuximabChemistry, PharmaceuticalDrug CarriersDrug StabilityFemaleFluorocarbonsGadoliniumHumansMiceMice, Inbred BALB CMicroscopy, Electron, TransmissionNanoparticlesAntineoplastic Agents, ImmunologicalCetuximabDrug CarriersFluorocarbonsGadoliniumperflexaneapoptosisGadolium nanoassemblyin vivo antitumor efficacythyroid cancerultrasound diagnosis

Identifiers

PMID33709843
PMCPMC7971338
OpenAlexW3134306523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.