Evidence map›Paper›PMID 33709628›Full record

ArticleESC heart failure2021

Diagnostic and prognostic implications of heart failure with preserved ejection fraction scoring systems.

Vibhu Parcha, Gargya Malla, Rajat Kalra, Nirav Patel, Sandra Sanders-van Wijk, Ambarish Pandey, Sanjiv J Shah, Garima Arora, Pankaj Arora

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Vibhu ParchaDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Gargya MallaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Rajat KalraCardiovascular Division, University of Minnesota, Minneapolis, MN, USA.
Nirav PatelDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sandra Sanders-van WijkCardiovascular Research Institute Maastricht, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.
Ambarish PandeyDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sanjiv J ShahFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Garima AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Pankaj AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USMaastricht University Medical Centre · NLNorthwestern University · USThe University of Texas Southwestern Medical Center · USUniversity of Minnesota · US

Funding

Race, Natriuretic Peptides and Physiological PerturbationsK23HL146887 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ARORA, PANKAJ · 2019 to 2023
$969k
Evaluation of Racial Differences in Cardiorespiratory Fitness Decline with Aging & Underlying Biological MechanismsR03AG067960 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PANDEY, AMBARISH · 2020 to 2021
$327k
NHLBI NIH HHS K23 HL146887NIA NIH HHS R03 AG067960
6 · The paper itself

Abstract

aimsWe sought to compare the generalizability and prognostic implications of heart failure with preserved ejection fraction (HFpEF) scores (HFA-PEFF and H METHODS AND

resultsBased on the respective scores, the study participants from the TOPCAT (N = 356), RELAX (N = 216), and ARIC (N = 379) studies were categorized as having a low, intermediate, or high likelihood of HFpEF. Age, sex, and race matched controls free of cardiovascular disease who had unexplained dyspnoea were used to evaluate the diagnostic performance. The prognostic value of scores was assessed using multivariable-adjusted Cox regression analyses. The median HFA-PEFF scores in the TOPCAT, RELAX, and ARIC studies were 5.0 [interquartile range (IQR): 5.0-6.0], 4.0 (IQR: 2.0-4.0), and 3.0 (IQR: 2.0-4.0), respectively. The median H

conclusionsThe HFA-PEFF and the H

Indexed as

Heart FailureDyspneaHumansMineralocorticoid Receptor AntagonistsPrognosisStroke VolumeMineralocorticoid Receptor AntagonistsCardiovascular outcomesDiagnosisHeart failureHeart failure preserved ejection fractionPrognosis

Identifiers

PMID33709628
PMCPMC8120372
OpenAlexW3133658409

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.