Evidence map›Paper›PMID 33709178›Full record

ReviewRheumatology international2022

Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review.

Simon Cadiou, Antonia Le Gruyer, Baptiste Giguet, François Robin, Morgane Milin, Xavier Guennoc, Pascal Guggenbuhl, Marine De Saint-Riquier

Open access · greenAbstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Simon CadiouDepartment of Rheumatology, Rennes University Hospital, Rennes 1 University, 35000, Rennes, France. simon.cadiou@chu-rennes.fr.ORCID 0000-0002-4846-6956
Antonia Le GruyerDepartment of Hepato-Gastroenterology, Saint-Brieuc Hospital, 22000, Saint-Brieuc, France.
Baptiste GiguetDepartment of Hepato-Gastroenterology, Rennes Univsersity Hospital, Rennes 1 University, 35000, Rennes, France.
François RobinDepartment of Rheumatology, Rennes University Hospital, Rennes 1 University, 35000, Rennes, France.
Morgane MilinDepartment of Rheumatology, Saint-Brieuc Hospital, 22000, Saint-Brieuc, France.
Xavier GuennocDepartment of Rheumatology, Saint-Brieuc Hospital, 22000, Saint-Brieuc, France.
Pascal GuggenbuhlDepartment of Rheumatology, Rennes University Hospital, Rennes 1 University, 35000, Rennes, France.ORCID 0000-0002-8260-1824
Marine De Saint-RiquierDepartment of Rheumatology, Saint-Brieuc Hospital, 22000, Saint-Brieuc, France.
Centre Hospitalier de Saint-Brieuc · FRUniversité Rennes 2 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium pyrophosphate deposition (CPPD) can be induced by a persistent hypomagnesemia. Tacrolimus is an immunosuppressive treatment especially used in organ transplant, potentially inducer of hypomagnesemia by renal loss. A 53-year-old man, liver transplant 10 months earlier, developed an acute peripheral oligoarthritis of wrist, hip and elbow with fever, associated with acute low back pain. Synovial fluid was sterile, and revealed calcium pyrophosphate crystals. Spinal imaging showed inflammatory changes. Magnesium blood level was low at 0.51 mmol/l, with high fractional excretion in favor of renal loss. Tacrolimus was changed for everolimus, proton pump inhibitor was stopped, and magnesium oral supplementation was started. After 8 months follow-up and slow prednisone tapering, he did not relapse pain. Persistent hypomagnesemia is a rare secondary cause of CPPD. In this entity, drug liability should be investigated such as tacrolimus in organ transplant patient.

Indexed as

CalcinosisChondrocalcinosisLiver TransplantationCalcium PyrophosphateHumansMagnesiumMaleMiddle AgedSynovial FluidTacrolimusCalcium PyrophosphateMagnesiumTacrolimusCPPDCrystalLiver transplantMagnesiumPyrophosphate calciumSpondylodiscitisTacrolimusVertebral osteomyelitis

Identifiers

PMID33709178
OpenAlexW3135724477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.