Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1.
Adam Ponedal, Shengshuang Zhu, Anthony J Sprangers, Xiao-Qi Wang, David C Yeo, Daniel C S Lio, Mengjia Zheng, Matthew Capek, Suguna P Narayan, Brian Meckes and 3 more
Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 3 institutions in 3 countries.
Adam PonedalDepartment of Chemical and Biological Engineering and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-9863-2580
Shengshuang ZhuInternational Institute for Nanotechnology and Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Anthony J SprangersInternational Institute for Nanotechnology and Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Xiao-Qi WangDepartment of Dermatology, Northwestern University, Chicago, Illinois 60611, United States.
David C YeoSchool of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 639798.
Daniel C S LioSchool of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 639798.
Mengjia ZhengSchool of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 639798.
Matthew CapekInternational Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.
Suguna P NarayanInternational Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.
Brian MeckesInternational Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States; Department of Biomedical Engineering, University of North Texas, Denton, Texas 76203, United States.ORCID 0000-0002-8389-4622
Amy S PallerDepartment of Dermatology, Northwestern University, Chicago, Illinois 60611, United States.ORCID 0000-0001-6187-6549
Chenjie XuDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China.ORCID 0000-0002-8278-3912
Chad A MirkinDepartment of Chemical and Biological Engineering, International Institute for Nanotechnology, Department of Materials Science and Engineering, and Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-6634-7627
Northwestern University · USNanyang Technological University · SGCity University of Hong Kong · HK
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Project 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7M
Northwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2019 to 2026
$6.6M
The Role of Keratinocytes as Independent ThermosensorsP30AR057216 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY S · 2009 to 2018
$6.0M
Neuron-Keratinocyte Communication in the Epidermis in Normal and Diabetic Wound HealingR01AR077691 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MENICHELLA, DANIELA M, PALLER, AMY S · 2020 to 2023
$2.6M
Glycosphingolipids Mediate Diabetic Wound Healing ImpairmentR01AR068375 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY S · 2016 to 2020
Abnormal scarring is a consequence of dysregulation in the wound healing process, with limited options for effective and noninvasive therapies. Given the ability of spherical nucleic acids (SNAs) to penetrate skin and regulate gene expression within, we investigated whether gold-core SNAs (AuSNAs) and liposome-core SNAs (LSNAs) bearing antisense oligonucleotides targeting transforming growth factor beta 1 (TGF-
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
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