Evidence map›Paper›PMID 33709049›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2021

Maternal exposure to PM

Marnie F Hazlehurst, Kecia N Carroll, Christine T Loftus, Adam A Szpiro, Paul E Moore, Joel D Kaufman, Kipruto Kirwa, Kaja Z LeWinn, Nicole R Bush, Sheela Sathyanarayana and 4 more

Open access · goldAbstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Adverse Effects of Carbon Black Nanoparticles on Maternal and Fetal Lungs in Pregnant Mice: Insights From a Metabolomics Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Prenatal PMRespirology (Carlton, Vic.) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Wildfire Seasons, Prenatal PMACS ES&T air · 2024
    Article
  13. Article
  14. Photobiomodulation Mitigates PMAntioxidants (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Associations of prenatal ambient air pollution exposures with asthma in middle childhood.International journal of hygiene and environmental health · 2024
    Article
  17. Maternal stressful life events during pregnancy and childhood asthma and wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Marnie F HazlehurstDepartment of Epidemiology, University of Washington, Box 357236, Seattle WA, USA 98195-7236.
Kecia N CarrollDivision of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Avenue, Nashville TN, USA, 37212.
Christine T LoftusDepartment of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle WA, USA, 98195-7234.
Adam A SzpiroDepartment of Biostatistics, University of Washington, Box 35732, Seattle WA, USA, 98195-7232.
Paul E MooreDivision of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, Nashville TN, USA, 37232-9500.
Joel D KaufmanDepartment of Epidemiology, University of Washington, Box 357236, Seattle WA, USA 98195-7236.
Kipruto KirwaDepartment of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle WA, USA, 98195-7234.
Kaja Z LeWinnDepartment of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, 401 Parnassus Ave, San Francisco CA, USA, 94143.
Nicole R BushDepartment of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, 401 Parnassus Ave, San Francisco CA, USA, 94143.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle WA, USA, 98195-7234.
Frances A TylavskyDepartment of Preventive Medicine, University of Tennessee Health Science Center, 66 N Pauline Street, Suite 633, Memphis TN, USA, 38163.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers School of Public Health, 683 Hoes Lane West, Piscataway NJ, USA, 08854.
Ruby H N NguyenDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S 2nd Street, Suite 300, Minneapolis MN, USA 55454.
Catherine J KarrDepartment of Epidemiology, University of Washington, Box 357236, Seattle WA, USA 98195-7236.
University of Washington · USUniversity of California, San Francisco · USVanderbilt University Medical Center · USMinnesota Department of Health · USRutgers, The State University of New Jersey · USUniversity of Tennessee Health Science Center · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway HealthR01ES025169 · NIEHS · SEATTLE CHILDREN'S HOSPITAL · PI Sheela Sathyanarayana · 2015 to 2026
$9.5M
The Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0M
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung FunctionR01HL132338 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE, WRIGHT, ROSALIND J · 2017 to 2021
$3.8M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
Environmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2M
Midcareer Investigator Award in Patient-Oriented Research in Pediatric AsthmaK24HL150312 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KECIA Nicole CARROLL · 2020 to 2026
$805k
EPA RD838300NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K24 HL150312NHLBI NIH HHS R01 HL109977NHLBI NIH HHS R01 HL132338NIA NIH HHS P01 AG055367NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES025169NIEHS NIH HHS R01 ES025888NIH HHS UH3 OD023271
6 · The paper itself

Abstract

backgroundIncreasingly studies suggest prenatal exposure to air pollution may increase risk of childhood asthma. Few studies have investigated exposure during specific fetal pulmonary developmental windows.

objectiveTo assess associations between prenatal fine particulate matter exposure and asthma at age 4.

methodsThis study included mother-child dyads from two pregnancy cohorts-CANDLE and TIDES-within the ECHO-PATHWAYS consortium (births in 2007-2013). Three child asthma outcomes were parent-reported: ever asthma, current asthma, and current wheeze. Fine particulate matter (PM

resultsChildren (n=1469) were on average 4.3 (standard deviation 0.5) years old, 49% were male, and 11.7% had ever asthma; 46% of women identified as black and 53% had at least a college/technical school degree. A 2 μg/m

conclusionsLater phases of prenatal lung development may be particularly sensitive to the developmental toxicity of PM

Indexed as

Air pollutionchild asthmaDevelopmental Origins of Health and Disease (DOHaD)particulate matterPM2.5prenatal

Identifiers

PMID33709049
PMCPMC7943175
OpenAlexW3133491036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.