Evidence map›Paper›PMID 33708967›Full record

ArticleAnnals of translational medicine2021

Aerobic exercise improves cardiac function in rats with chronic heart failure through inhibition of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1).

Ling Hu, Ya-Nan Xu, Qian Wang, Mei-Jie Liu, Ping Zhang, Lan-Ting Zhao, Fang Liu, Dong-Yan Zhao, He-Nan Pei, Xing-Bao Yao and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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  15. Heart failure, inflammation and exercise.International journal of biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ling HuDepartment of Internal Medicine, Beijing Xiaotangshan Hospital, Beijing, China.
Ya-Nan XuDepartment of Cardiopulmonary Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
Qian WangDepartment of Sports Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
Mei-Jie LiuMedical Experiment Center, China Academy of Chinese Medical Sciences, Beijing, China.
Ping ZhangDepartment of Cardiology, Beijing Tsinghua Changgung Hospital affiliated with Tsinghua University, Beijing, China.
Lan-Ting ZhaoDepartment of Cardiology, Beijing Tsinghua Changgung Hospital affiliated with Tsinghua University, Beijing, China.
Fang LiuDepartment of Cardiology, Beijing Tsinghua Changgung Hospital affiliated with Tsinghua University, Beijing, China.
Dong-Yan ZhaoDepartment of Cardiopulmonary Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
He-Nan PeiDepartment of Sports Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
Xing-Bao YaoDepartment of Sports Injury, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, China.
Hua-Gang HuResearch Office, Beijing Xiaotangshan Hospital, Beijing, China.
Tang Hospital · CNTsinghua University · CNBeijing Tsinghua Chang Gung Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the beneficial effects and underlying mechanisms of aerobic exercise on chronic heart failure (CHF).

methodsA CHF rat model was induced via left anterior descending coronary artery ligation. Four weeks post-surgery, CHF rats received aerobic exercise training over an 8-week period and cardiac function indexes including xxx were analyzed. To investigate the mechanisms involved in the aerobic exercise-induced benefits on CHF, overexpression of the long non-coding RNA MALAT1 was examined both

resultsCompared to the control group, the CHF rats showed evidence of left ventricular dysfunction including aggravated cardiac function indexes and lung to body weight ratio. The Masson staining demonstrated a significant degree of blue-stained fibrotic myocardial tissue in CHF rats compared to control rats. Furthermore, the levels of collagen I and collagen II were also markedly increased in CHF rats. Aerobic exercise improved cardiac function and left ventricular remodeling in rats with CHF. There was a significant reduction in the levels of the reactive oxygen species (ROS), inflammatory cytokines including TNF-α, IL-6, and IL-1β, and inflammatory mediums containing the matrix metalloproteinases (MMPs) MMP-2 and MMP-9. Moreover, CHF rats receiving aerobic exercise showed decreased myocardial apoptosis and increased expression of autophagy-related proteins including beclin-1 and LC3B-II. Overexpression of the lncRNA MALAT1 eliminated all the beneficial effects related to aerobic exercise in CHF rats. Subsequent investigations demonstrated that miR-150-5p expression was up-regulated in CHF-Tr rats and down-regulated in CHF-Tr-MALAT1 rats. Furthermore, the downstream PI3K/Akt signaling pathway was re-activated in CHF-Tr-MALAT1 rats.

conclusionsAerobic exercise improved cardiac function through inhibition of the lncRNA MALAT1 in CHF, and the potential mechanisms may be mediated via the miR-150-5p/PI3K/Akt signaling pathway.

Indexed as

Aerobic exercisechronic heart failure (CHF)metastasis-associated lung adenocarcinoma transcript 1

Identifiers

PMID33708967
PMCPMC7944272
OpenAlexW3131478281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.