Evidence map›Paper›PMID 33708849›Full record

ArticleAnnals of translational medicine2021

Interleukin (IL)-1 family cytokines could differentiate primary immune thrombocytopenia from systemic lupus erythematosus-associated thrombocytopenia.

Yanxia Zhan, Luya Cheng, Boting Wu, Lili Ji, Pu Chen, Feng Li, Jingjing Cao, Yang Ke, Ling Yuan, Zhihui Min and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Novel Biomarkers for Diagnosis and Monitoring of Immune Thrombocytopenia.International journal of molecular sciences · 2023
    Review
  9. IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yanxia ZhanDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Luya ChengDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Boting WuDepartment of Transfusion Medicine, Zhongshan Hospital Fudan University, Shanghai, China.
Lili JiDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Pu ChenDepartment of Clinical Laboratory, Zhongshan Hospital Fudan University, Shanghai, China.
Feng LiDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Jingjing CaoDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Yang KeDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Ling YuanDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Zhihui MinInstitute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai, China.
Lihua SunDepartment of Clinical Laboratory, Zhongshan Hospital Fudan University, Shanghai, China.
Hao ChenDepartment of Thoracic Surgery, Zhongshan Hospital Xuhui Branch, Fudan University, Shanghai, China.
Fanli HuaDepartment of Hematology, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China.
Yunfeng ChengDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.
Zhongshan Hospital · CNFudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary immune thrombocytopenia (ITP) is an autoimmune-mediated disorder characterized by a decreased platelet count. Systemic lupus erythematosus (SLE) is also an autoimmune disease in which thrombocytopenia is a common hematologic manifestation. Interleukin (IL)-1 family cytokines are major proinflammatory and immunoregulatory mediators. This study aimed to investigate the role of IL-1 cytokines in patients with ITP and SLE and the potential pathophysiologic mechanism to differentiate SLE-associated thrombocytopenia (SLE-TP) from ITP.

methodsMultiplex cytokine assay and real-time polymerase chain reaction (RT-PCR) were used to measure IL-1 cytokines in 17 newly diagnosed ITP patients, 17 SLE-TP patients, 19 SLE patients without thrombocytopenia (SLE-NTP), and 10 healthy controls.

resultsThe serum levels of IL-1β, IL-18, IL-36α, IL-36β, IL-36γ, and IL-33 were decreased significantly in ITP patients compared with SLE-TP patients, SLE-NTP patients, and healthy controls (P<0.05). While there was no significant difference in the serum level of IL-37 between ITP and SLE-TP patients, there was a positive correlation between the platelet count and IL-37 level in ITP patients. Our data suggested that serum IL-1β, IL-18, IL-36α, IL-36β, IL-36γ, IL-33, and IL-37 could be considered biomarkers in the diagnosis of ITP.

conclusionsSerum IL-1β, IL-18, IL-36α, IL-36β, IL-36γ, and IL-33 could be considered biomarkers to differentiate SLE-TP from ITP patients.

Indexed as

biomarker)biomarker (IL-1 cytokine familyinterleukin-1 cytokine familyPrimary immune thrombocytopenia (primary ITP)systemic lupus erythematosus (SLE)

Identifiers

PMID33708849
PMCPMC7940935
OpenAlexW3128373785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.