ArticleAnnals of translational medicine2021
Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk of Heart Failure between Different Metabolic States of Health and Weight: A Meta-Analysis of Cohort Studies.Nutrients · 2022Pooled it
- Risk of Stroke Among Different Metabolic Obesity Phenotypes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Associations of body mass index and metabolic health with stroke risk in a large prospective cohort with time updated covariates.Scientific reports · 2026Article
- The Global Obesity Epidemic: Epidemiology, Health Burden and Policy Priorities.European cardiology · 2026Review
- Prevalence and impact of metabolically healthy obesity on cardiovascular outcomes in postmenopausal women and disparities: An age-matched study.World journal of cardiology · 2025Article
- Positive relationship between Work-to-Sleep hours Ratio and obesity: a cross-sectional study, evidence from NHANES 2017-2023.Frontiers in public health · 2025Article
- Article
- Different associations between body mass index and Alzheimer's markers depending on metabolic health.Alzheimer's research & therapy · 2024Article
- Atrial High-Rate Episodes in Elderly Patients: The Anticoagulation Therapy Dilemma.Journal of clinical medicine · 2024Review
- Metabolically healthy obesity and health risks - a review of meta-analyses.Central European journal of public health · 2024Review
- Thyroid stimulating hormone correlates with triglyceride levels but is not associated with the severity of acute ischemic stroke in patients with euthyroidism: a cross-sectional study.Annals of translational medicine · 2023Article
- Temporal trends in the prevalence of metabolically healthy overweight and obesity in Korean youth: data from the Korea National Health and Nutrition Examination Survey 2011-2019.Annals of pediatric endocrinology & metabolism · 2022Article
- Transition from metabolically healthy to unhealth status associated with risk of carotid artery plaque in Chinese adults.BMC cardiovascular disorders · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic healthy obesity (MHO) is a unique subgroup of overweight and obese individuals with normal metabolic characteristics. Its association with the risk of stroke remains unclear. We aimed to examine the risk of stroke in MHO individuals and the further associations between stroke and metabolic abnormalities under different bodyweight conditions.
methodsWe systematically searched PubMed, Embase and Cochrane Library from December 1946 to January 2019, and only included prospective cohort studies. Random effects models were used to evaluate the pooled risk ratios (RR) and 95% confidence intervals (95% CI) of incident stroke.
resultsA total of eight studies comprising 4,256,888 participants were included in the meta-analysis. MHO individuals had an increased risk of stroke compared with metabolically healthy normal weight (MH-NW) individuals (RR =1.17, 95% CI: 1.11-1.23). However, the stroke risk of metabolically healthy overweight individuals was the same (RR =1.02, 95% CI: 0.84-1.23). All groups with unhealthy metabolism had a similarly elevated risk: normal weight (RR =1.83, 95% CI: 1.57-2.14), overweight (RR =1.93, 95% CI: 1.44-2.58), and obesity (RR =2.00, 95% CI: 1.40-2.87).
conclusionsThe meta-analysis confirms a positive association between MHO phenotype and the risk of stroke. Individuals with metabolic abnormalities under different bodyweight conditions are at elevated risk.
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