ArticleAnnals of translational medicine2021
Analysis of endometrial microbiota in intrauterine adhesion by high-throughput sequencing.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Study on Risk Factors Related to Intrauterine Adhesion Based on Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Postbiotic-Based Regenerative Therapy for Intrauterine Adhesions: Mechanisms, Microbiota Crosstalk, and Translational Perspectives.Probiotics and antimicrobial proteins · 2026Review
- Microbiological Profiling of Menstrual Blood Aspirated from the Uterus in Patients Undergoing Frozen Embryo Transfer.Diagnostics (Basel, Switzerland) · 2026Article
- Mechanisms by Which the Cervicovaginal Microbiota Mediates Endometrial Repair Following Uterine Injury: A Review of Recent Advances.International journal of general medicine · 2026Review
- Article
- Preventive effects of sodium hyaluronate combined with pelvic floor neuromuscular electrical stimulation on the intrauterine adhesions in women after abortion.Biomolecules & biomedicine · 2024Article
- Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion.Scientific reports · 2023Article
- Endometrial microbiota in women with and without adenomyosis: A pilot study.Frontiers in microbiology · 2023Article
- Research progress in the correlation between reproductive tract microbiota and intrauterine adhesion.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Review
- Endometrial microbiome: sampling, assessment, and possible impact on embryo implantation.Scientific reports · 2022Article
- Bacterial colonization at caesarean section defects in women of secondary infertility: an observational study.BMC pregnancy and childbirth · 2022Observational
- Visual Analysis of Uterine Adhesion Research Based on CiteSpace: Bibliometric Analysis From 2006 to 2021.Frontiers in reproductive health · 2022Article
- Rabbit microbiota across the whole body revealed by 16S rRNA gene amplicon sequencing.BMC microbiology · 2021Article
- Erratum to analysis of endometrial microbiota in intrauterine adhesion by high-throughput sequencing.Annals of translational medicine · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrauterine adhesions (IUA) arise from scar tissue formation between the endometrial surfaces in response to mechanical or infectious injuries. However, the potential role of endometrial microbiota in IUA remains unclear. We aimed to explore the composition of endometrial microbiota and its potential role in IUA.
methodsWe retrospectively enrolled 46 patients diagnosed with IUA and 21 infertility patients without intrauterine lesions, as control subjects. All cases were diagnosed with hysteroscopy and endometrial tissues were taken from the intrauterine cavity using a hysteroscopic cutting ring without electricity study. After endometrial samples were collected, DNA was extracted and amplified for barcoded Illumina high-throughput next-generation sequencing targeted to the 16S rRNA V4 region for microbiota. Microbiota data were compared between two groups using α-diversity, β-diversity and Nonmetric Multidimensional Scaling based on Weighted Unifrac distance.
resultsAt the phyla level, the dominant bacteria included Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria. Proteobacteria accounted for more than 64.48%. At the genus level, the proportions of Klebsiella, Shewanella, and Lactobacillus were higher in patients with IUA than in non- IUA participants (20.67% and 8.77%, P=0.006, 13.37% and 4.53%, P=0.175, 12.74% and 6.95%, P=0.882; respectively). The proportion of Acinetobacter was significantly lower in patients with IUA than in non- IUA participants (P=0.005).
conclusionsEndometrial microbiota differ between patients with IUA and infertility patients without intrauterine lesions, and the potential variation of endometrial microbiota might cause IUA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.