Evidence map›Paper›PMID 33708728›Full record

ArticleIranian journal of public health2020

Pyrrolidinedithiocarbamic Acid Ammonium Salt Inhibits Apoptosis and Phenotypic Transformation of Co-Culture of Myeloma Cells and Renal Tubular Epithelial Cells by Reducing the Secretion of Light Chain Protein.

Xiaoyan Yu, Jie Bao, Xinyu Cui, Fengxia DU, Yuefei Wang, Lili Bi, Jun Sun, Ling Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoyan YuDepartment of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Jie BaoDepartment of Hematopathology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Xinyu CuiDepartment of Hematopathology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Fengxia DUDepartment of Pathogenic Biology, Qiqihar Medical University, Qiqihar161006, P.R. China.
Yuefei WangDepartment of Physiology, Qiqihar Medical University, Qiqihar161006, P.R. China.
Lili BiDepartment of Hematopathology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Jun SunDepartment of Hematopathology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Ling LiDepartment of Hematopathology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar161000, P.R. China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigate the effects of NFϰB inhibitor pyrrolidinedithiocarbamic acid ammonium salt (PDTC) on the viability, apoptosis and cell phenotype of HK-2 cells in the co-culture system of myeloma cells in renal tubular epithelial cells.

methodsThis study was performed in Qiqihar Medical University,

resultsPDTC significantly increased the viability of HK-2 cells. PDTC reduced the apoptosis of renal tubular epithelial cells. After PDTC treatment, the expression of cell surface marker E-cadherin decreased, and the expression of α-SMA increased, which induced the renal interstitial fibrosis. The secretion of ϰ light chain and λ light chain of RPMI-8226 cells was significantly decreased after the addition of PDTC, but the ratio was not changed.

conclusionPDTC can inhibit the cell activity, promote apoptosis, and reduce the secretion of secretion of ϰ light chain and λ light chain through inhibiting the NF-ϰB pathway activation of myeloma cell RPMI-8226.

Indexed as

Light chain proteinMyeloma nephropathyRenal tubular epithelial cells

Identifiers

PMID33708728
PMCPMC7917491
OpenAlexW3100478809

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.