ArticleFrontiers in oncology2020
Scale-Free Analysis of Intraoperative ECoG During Awake Craniotomy for Glioma.
Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Surgical identification of brain tumour margins through impedance monitoring and electrocorticography and the potential for their combined use: A systematic review.Neurosurgical review · 2024Pooled it
- Management Guidelines for the Treatment of Pediatric Brain Tumor-Associated Seizure: A Modified Delphi Consensus Report.Annals of the Child Neurology Society · 2026Article
- NeuroDepth: an ultra long whole brain reachable multi-channel probe for real-time precise functional localization of deep human brain tumor margins.Microsystems & nanoengineering · 2025Article
- Article
- Differentiation of tumor versus peritumoral cortex in gliomas by intraoperative electrocorticography.Neuro-oncology · 2025Article
- Neurosurgical and BCI approaches to visual rehabilitation in occipital lobe tumor patients.Heliyon · 2024Article
- The association between pan-immune-inflammation value and survival in head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Polymer nanofiber network reinforced gold electrode array for neural activity recording.Biomedical engineering letters · 2023Article
- Benign Glioma.Advances in experimental medicine and biology · 2023Article
- Review
- Intraoperative mapping of epileptogenic foci and tumor infiltration in neuro-oncology patients with epilepsy.Neuro-oncology advancesArticle
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8 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrocorticography (ECoG) has been utilized in many epilepsy cases however, the use of this technique for evaluating electrophysiological changes within tumoral zones is spare. Nonetheless, epileptic activities seem to arise from the neocortex surrounding the gliomas suggesting a link between epileptogenesis and glioma cell infiltration in the peritumoral area. The purpose of this study was to implement novel scale-free measures to assess how cortical physiology is altered by the presence of an invasive brain tumor.
methodsTwelve patients undergoing an awake craniotomy for resection of a supratentorial glioma were included. ECoG data over the main tumor and the exposed surroundings was acquired intra-operatively just prior to tumor resection. Six of the patients presented with seizures and had data acquired both in the awake and anesthetic state. The corresponding anatomical location of each electrode in relation to the macroscopically-detectable tumor was recorded using the neuronavigation system based on structural anatomical images obtained pre-operatively. The electrodes were classified into tumoral, healthy or peritumoral based on the macroscopically detectable tumoral tissue from the pre-operative structural MRI.
resultsThe electrodes overlying the tumoral tissue revealed higher power law exponent (PLE) values across tumoral area compared to the surrounding tissues. The difference between the awake and anesthetic states was significant in the tumoral and healthy tissue (p < 0.05) but not in the peritumoral tissue. The absence of a significant PLE reduction in the peritumoral tissue from the anesthetic to the awake state could be considered as an index of the presence or absence of infiltration of tumor cells into the peritumoral tissue.
conclusionsThe current study portrays for the first time distinct power law exponent features in the tumoral tissue, which could provide a potential novel electrophysiological marker in the future. The distinct features seen in the peritumoral tissue of gliomas seem to indicate the area where both the onset of epileptiform activity and the tumor infiltration take place.
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