ArticleTranslational pediatrics2021
The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns.
Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors.Pediatric research · 2026Article
- A comparative study on infant growth between assisted reproductive technology pregnancy and natural pregnancy.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Effects of maternal isolated oligohydramnios on blood metabolic profile in term neonates: a retrospective observational study.BMC pregnancy and childbirth · 2025Observational
- Impact of maternal anemia during pregnancy on neonatal metabolic profiles: evidence from the Beijing Birth Cohort Study.BMC pregnancy and childbirth · 2025Observational
- Effects of combined spinal-epidural anesthesia and epidural analgesia on pain and blood pressure in preeclamptic women undergoing painless delivery.American journal of translational research · 2025Article
- The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels.Frontiers in nutrition · 2025Article
- Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies.Frontiers in immunology · 2024Article
- Effect of hypertensive disorders of pregnancy on peripheral venous blood cell count in preterm infants with a gestational age of 28-34 weeks.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy-induced hypertension (PIH) is associated with an increased number of neonatal complications, but its impact on neonatal metabolism remains unclear. This study aimed to investigate the differential metabolomics of infants born to mothers with and without PIH.
methodsBlood samples of a total of 115 infants born to mothers with (n=56) and without (n=59) PIH were collected and assigned to two groups, respectively, from the neonatal department of Sixth Affiliated Hospital of Sun Yat-Sen University. A tandem mass spectrometer was used to generate metabolic profiling of amino acid, free carnitine, and acyl-carnitines. The resulting data were analyzed using orthogonal partial least squares discriminant analysis based on the difference between infants born to mothers with or without PIH.
resultsA significant relationship was observed between the two groups (with and without PIH) in the metabolic fingerprint. According to the pattern recognition analysis combined with variance importance, 25 metabolites with high importance were found. The top ten substances were selected for analysis. Compared with infants born to mothers without PIH, glycine levels increased, and C14DC, C22, C4DC, C5:1, C6DC, C5-OH, proline, C14-OH, and C20 decreased in infants born to mothers with PIH.
conclusionsUsing liquid chromatography (LC)-MS/MS metabolomics, a significant relationship was detected between neonatal metabolism and maternal hypertension. It is important to correct the subsequent infantile metabolic disorder by balancing the biomarker metabolites and suppling adequate nutrition to improve the health and growth of newborns of PIH mothers.
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