Evidence map›Paper›PMID 33708441›Full record

ArticleCardiology research and practice2021

Impact of Platelet Glycoprotein Ia/IIa C807T Gene Polymorphisms on Coronary Artery Aneurysms of KD Patients.

Wei Li, Lei Pi, Jia Yuan, Xueping Gu, Zhouping Wang, Yunfeng Liu, Qiulian Deng, Yanfei Wang, Ping Huang, Li Zhang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
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Article in Cardiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wei LiDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.
Lei PiDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Jia YuanDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.
Xueping GuDepartment of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Zhouping WangDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-3449-7687
Yunfeng LiuDepartment of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Qiulian DengDepartment of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Yanfei WangDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.
Ping HuangDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.
Li ZhangDepartment of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-0712-0112
Xiaoqiong GuDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.ORCID https://orcid.org/0000-0002-9558-4226
Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKawasaki disease (KD) is a systemic vasculitis of unknown etiology in children. Coronary artery abnormalities are the most common complications of KD. Recent evidence showed that genetic polymorphisms may lead to susceptibility to KD. Genetic variants in platelet glycoprotein have been reported to be associated with coronary artery disease. The aim of the present study is to investigate the correlation between the role of platelet glycoprotein and coronary artery aneurysms in KD patients.

methodsWe did a case-control study that enrolled 818 KD patients and 1401 healthy children with the same age and sex from January 2013 to December 2016. Analysis of single-nucleotide polymorphism (rs1126643) of the platelet glycoprotein Ia/IIa C807T was performed by multiplex polymerase chain reactions in this study.

resultsA significant difference in the genotype distribution between KD cases and controls was observed for the glycoprotein Ia/IIa C807T (rs1126643) polymorphism (

conclusionsThe platelet glycoprotein Ia/IIa T allele carriers may have a protective effect on the risk of coronary artery aneurysms of KD patients, especially in females and children aged less than 60 months. These results may provide evidence for platelet glycoprotein Ia/IIa gene polymorphisms in the pathogenesis of KD patients.

Identifiers

PMID33708441
PMCPMC7929693
OpenAlexW3132199017

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