ArticleVirus evolution2021
Hepatitis delta virus-like circular RNAs from diverse metazoans encode conserved hammerhead ribozymes.
Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- A newly established reverse genetic system for a circular RNA virus reveals new requirements for infection and its biocontrol potential.Science advances · 2026Article
- A replication-competent deltavirus from the marsupial fat-tailed dunnartThe Journal of general virology · 2026Article
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- Diversity and evolution of viroids and viroid-like agents with circular RNA genomes revealed by metatranscriptome mining.Nucleic acids research · 2025Article
- Article
- Uncovered diversity of infectious circular RNAs: A new paradigm for the minimal parasites?Npj viruses · 2024Review
- Method for Quantitative HDV RNA Detection: I, Manual Workflow (Serum and Liver Tissue) and II, Fully Automated High Throughput Workflow for Diagnostic Use.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture.RNA biology · 2024Article
- Hybrids of RNA viruses and viroid-like elements replicate in fungi.Nature communications · 2023Article
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- On the early identification and characterization of pear blister canker viroid, apple dimple fruit viroid, peach latent mosaic viroid and chrysanthemum chlorotic mottle viroid.Virus research · 2023Article
- The RNA virosphere: How big and diverse is it?Environmental microbiology · 2023Article
- A changing landscape: Tracking and analysis of the international HDV epidemiology 1999-2020.PLOS global public health · 2023Article
- Article
- Viroids and Viroid-like Circular RNAs: Do They Descend from Primordial Replicators?Life (Basel, Switzerland) · 2022Article
- Article
- A scenario for the emergence of protoviroids in the RNA world and for their further evolution into viroids and viroid-like RNAs by modular recombinations and mutations.Virus evolution · 2022Review
- Viruses Defined by the Position of the Virosphere within the Replicator Space.Microbiology and molecular biology reviews : MMBR · 2021Article
- The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.RNA (New York, N.Y.) · 2021Article
- HDV-Like Viruses.Viruses · 2021Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Human hepatitis delta virus (HDV) is a unique infectious agent whose genome is composed of a small circular RNA. Recent data, however, have reported the existence of highly divergent HDV-like circRNAs in the transcriptomes of diverse vertebrate and invertebrate species. The HDV-like genomes described in amniotes such as birds and reptiles encode self-cleaving RNA motifs or ribozymes similar to the ones present in the human HDV, whereas no catalytic RNA domains have been reported for the HDV-like genomes detected in metagenomic data from some amphibians, fish, and invertebrates. Herein, we describe the self-cleaving motifs of the HDV-like genomes reported in newts and fish, which belong to the characteristic class of HDV ribozymes. Surprisingly, HDV-like genomes from a toad and a termite show conserved type III hammerhead ribozymes, which belong to an unrelated class of catalytic RNAs characteristic of plant genomes and plant subviral circRNAs, such as some viral satellites and viroids. Sequence analyses revealed the presence of similar HDV-like hammerhead ribozymes encoded in two termite genomes, but also in the genomes of several dipteran species.
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