Evidence map›Paper›PMID 33708359›Full record

ArticleJournal of extracellular vesicles2020

Hitting the Bullseye: Are extracellular vesicles on target?

Nicole Noren Hooten, María Yáñez-Mó, Rachel DeRita, Ashley Russell, Peter Quesenberry, Bharat Ramratnam, Paul D Robbins, Dolores Di Vizio, Sicheng Wen, Kenneth W Witwer and 1 more

Abstract readEditorial
In one paragraph

Article in Journal of extracellular vesicles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Rewiring cell identityNanomedicine (London, England) · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Small extracellular vesicle-mediatedCancer biology & therapy · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole Noren HootenLaboratory of Epidemiology and Population Science National Institute on Aging National Institutes of Health Baltimore Maryland USA.ORCID 0000-0002-1683-3838
María Yáñez-MóDepartamento de Biología Molecular UAM Centro de Biología Molecular Severo Ochoa IIS-IP Madrid Spain.
Rachel DeRitaDepartment of Cancer Biology Sidney Kimmel Cancer Center Jefferson University Philadelphia Pennsylvania USA.
Ashley RussellDepartment of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore Maryland USA.
Peter QuesenberryDivision of Hematology/Oncology The Warren Alpert Medical School of Brown University Providence Rhode Island USA.
Bharat RamratnamDepartment of Medicine Alpert Medical School Brown University Providence Rhode Island USA.
Paul D RobbinsInstitute on the Biology of Aging and Metabolism, and Department of Biochemistry Molecular Biology and Biophysics University of Minnesota Minneapolis Minnesota USA.
Dolores Di VizioDepartments of Surgery Biomedical Sciences, and Pathology & Laboratory Medicine Division of Cancer Biology and Therapeutics Cedars-Sinai Medical Center Los Angeles California USA.
Sicheng WenDivision of Hematology/Oncology The Warren Alpert Medical School of Brown University Providence Rhode Island USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore Maryland USA.
Lucia R LanguinoDepartment of Cancer Biology Sidney Kimmel Cancer Center Jefferson University Philadelphia Pennsylvania USA.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2025
$45.0M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
Role of Runx2 in prostate tumorigenesis and metastasisP01CA140043 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2010 to 2021
$12.2M
PROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2M
COBRE Center for Cancer Research DevelopmentP30GM110759 · NIGMS · RHODE ISLAND HOSPITAL · PI RAMRATNAM, BHARAT · 2015 to 2019
$6.3M
Next-generation extracellular vesicle biologics to target central nervous system and peripheral reservoirs of HIVR01AI144997 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMRATNAM, BHARAT, WITWER, KENNETH W · 2019 to 2023
$4.0M
Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette UseR01DA047807 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2018 to 2022
$3.7M
Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine AbuseR01DA040385 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2015 to 2019
$2.3M
Novel Approaches to Capture, Sorting, and Characterization of CNS-Origin Extracellular VesiclesR33MH118164 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACHAIRAKI, VASILIKI, WITWER, KENNETH W · 2020 to 2022
$2.2M
Integrin-mediated mechanisms of prostate cancer progressionR01CA224769 · NCI · THOMAS JEFFERSON UNIVERSITY · PI LANGUINO, LUCIA R. · 2018 to 2022
$2.0M
High-throughput palmitoyl-proteomics profiling of extracellular vesicles for identification of biomarkers for early detection of clinically significant prostate cancerR01CA218526 · NCI · CEDARS-SINAI MEDICAL CENTER · PI DI VIZIO, DOLORES, HURLEY, PAULA JILL · 2017 to 2021
$2.0M
NCI NIH HHS P01 CA140043NCI NIH HHS R01 CA218526NCI NIH HHS R01 CA224769NCI NIH HHS UG3 CA241694NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI144997NIA NIH HHS P01 AG043376NIA NIH HHS U19 AG056278NIDA NIH HHS R01 DA040385NIDA NIH HHS R01 DA047807NIGMS NIH HHS P30 GM110759NIGMS NIH HHS U54 GM115677NIMH NIH HHS R21 MH118164NIMH NIH HHS R33 MH118164
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Extracellular VesiclesAnimalsHumans

Identifiers

PMID33708359
PMCPMC7890543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.