Evidence map›Paper›PMID 33708291›Full record

Observational studyThe Pan African medical journal2019

Response to single dose hepatitis B vaccine in Congolese non-HIV hemodialysis patients: a prospective observational study.

Pitchou Yemasai Kengibe, Jean-Robert Risassy Makulo, Yannick Mayamba Nlandu, François Bompeka Lepira, Ernest Kiswaya Sumaili, Justine Busanga Bukabau, Charles Nlombi Mbendi, Steve Mundeke Ahuka, Antoine Wola Tshimpi, Patrick Kisoko Ngoma and 2 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Pan African medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05057936 (Antibody Response After COVID-19 Vaccination in Chronic Kidney Disease and Kidney Transplant Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05057936 completednot on this mapstarted 2021, after this paper: background citation

Antibody Response After COVID-19 Vaccination in Chronic Kidney Disease and Kidney Transplant Patients

TypeobservationalSponsorBangkok Metropolitan Administration Medical College and Vajira HospitalRan2021 to 2021Enrolled140ConditionsCovid19, Breakthrough Infection, CKD, Kidney TransplantArmsCOVID vaccine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pitchou Yemasai KengibeDivision of Hepato-gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Jean-Robert Risassy MakuloDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Yannick Mayamba NlanduDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
François Bompeka LepiraDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Ernest Kiswaya SumailiDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Justine Busanga BukabauDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Charles Nlombi MbendiDivision of Hepato-gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Steve Mundeke AhukaDivision of Microbiology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Antoine Wola TshimpiDivision of Hepato-gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Patrick Kisoko NgomaDivision of Hepato-gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Nseka Nazaire ManganiDivision of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Sebastien Nsukini MbendiDivision of Hepato-gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBecause of the cost, in the hemodialysis centers of Kinshasa, the double dose of hepatitis B (HBV) vaccine is administered only to HIV infected patients while other patients receive a single dose. This study aimed to evaluate the single-dose vaccination Protocol and identify determinants of seroconversion's lack of anti-HBs after vaccination schedule.

methods56 non-HIV chronic hemodialysis patients serologically negative for HBs Ag, anti-HBs and anti-HBc were selected between January 2014 and December 2016. The recombinant DNA vaccine (Euvax B

resultsIn the study group (mean age 55.6± 15.1 years; 73 % men, 36% diabetic and 86% hypertensive), low and highly protective vaccine responses were seen in 32% and 50% respectively versus 18% of patient had a lack of seroconversion. CRP > 6 mg/L (aOR: 8.96), hypoalbuminemia (aOR: 6.50) and KT/V < 1.2 (aOR: 3.70) were associated with the lack of seroconversion.

conclusionHalf of the patients in the study had either a lack or low protective vaccine response. Patient-related factors and hemodialysis parameters were the main factors associated with the lack of anti-HbS seroconversion. These results highlight the need to maximize doses of vaccine in all patients.

Indexed as

Renal DialysisAdultAgedDemocratic Republic of the CongoFemaleHepatitis BHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHumansMaleMiddle AgedProspective StudiesSeroconversionVaccinationVaccines, SyntheticEuvax-BHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesVaccines, Syntheticantibodies seroconversionHemodialysishepatitis B virusvaccination

Identifiers

PMID33708291
PMCPMC7906547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.