Evidence map›Paper›PMID 33708244›Full record

ArticleFrontiers in genetics2021

Effects of DNA Methylation on TFs in Human Embryonic Stem Cells.

Ximei Luo, Tianjiao Zhang, Yixiao Zhai, Fang Wang, Shumei Zhang, Guohua Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Somatic mutation as an explanation for epigenetic aging.bioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Computational Methods for Single-cell DNA Methylome Analysis.Genomics, proteomics & bioinformatics · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ximei LuoSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Tianjiao ZhangSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Yixiao ZhaiInformation and Computer Engineering College, Northeast Forestry University, Harbin, China.
Fang WangSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Shumei ZhangInformation and Computer Engineering College, Northeast Forestry University, Harbin, China.
Guohua WangSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Harbin Institute of Technology · CNNortheast Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is an important epigenetic mechanism for gene regulation. The conventional view of DNA methylation is that DNA methylation could disrupt protein-DNA interactions and repress gene expression. Several recent studies reported that DNA methylation could alter transcription factors (TFs) binding sequence specificity

Indexed as

CEBPBCTCFDNA methylationH1-hESCtranscription factors

Identifiers

PMID33708244
PMCPMC7940757
OpenAlexW3129344265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.