Evidence map›Paper›PMID 33708208›Full record

ArticleFrontiers in immunology2021

Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation.

Stefan Tukaj, Jagoda Mantej, Michał Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J Ludwig, Katja Bieber, Michael Kasperkiewicz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  11. Psoriasis, Is It a Microdamage of Our "Sixth Sense"? A Neurocentric View.International journal of molecular sciences · 2022
    Article
  12. Review
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  17. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Stefan TukajDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Jagoda MantejDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Michał SobalaDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Katarzyna PotrykusDepartment of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Zbigniew TukajDepartment of Plant Physiology and Biotechnology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Detlef ZillikensDepartment of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Ralf J LudwigLübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Katja BieberLübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Michael KasperkiewiczDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
University of Gdańsk · PLUniversity of Lübeck · DEUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock proteins (Hsp) are constitutive and stress-induced molecules which have been reported to impact innate and adaptive immune responses. Here, we evaluated the role of Hsp70 as a treatment target in the imiquimod-induced, psoriasis-like skin inflammation mouse model and related

Indexed as

Disease SusceptibilityAnimalsAntibodiesBiomarkersBiopsyCytokinesDermatitisDisease Models, AnimalFemaleHSP70 Heat-Shock ProteinsImmunizationImmunophenotypingInflammation MediatorsKeratinocytesMiceRecombinant ProteinsAntibodiesBiomarkersCytokinesHSP70 Heat-Shock ProteinsInflammation MediatorsRecombinant Proteinsheat shock proteinsHsp70immunizationpsoriasisregulatory T cellsTh17Treg

Identifiers

PMID33708208
PMCPMC7940535
OpenAlexW3132655338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.