Evidence map›Paper›PMID 33708167›Full record

ArticleFrontiers in neurology2021

Initial Method for Characterization of Tympanic Membrane Drug Permeability in Human Temporal Bones

Samuel Early, Rong Yang, Xiyu Li, Zipei Zhang, Jens C van der Valk, Xiaojie Ma, Daniel S Kohane, Konstantina M Stankovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. [Progress of tympanic administration with its application in the treatment of inner ear disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Samuel EarlyEaton-Peabody Laboratories, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United States.
Rong YangLaboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States.
Xiyu LiLaboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States.
Zipei ZhangLaboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States.
Jens C van der ValkEaton-Peabody Laboratories, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United States.
Xiaojie MaEaton-Peabody Laboratories, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United States.
Daniel S KohaneLaboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States.
Konstantina M StankovicEaton-Peabody Laboratories, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, United States.
Harvard University · USMassachusetts Eye and Ear Infirmary · USBoston Children's Hospital · USQilu Hospital of Shandong University · CNUniversity of California, San Diego · US

Funding

Trans-tympanic delivery of antibioticsR01DC015050 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI KOHANE, DANIEL S · 2016 to 2020
$2.8M
Mechanisms of sensorineural hearing loss: secreted factorsR01DC015824 · NIDCD · STANFORD UNIVERSITY · PI STANKOVIC, KONSTANTINA M · 2016 to 2020
$2.2M
Trans-Tympanic Drug Delivery for Treatment and Prophylaxis of Otitis MediaR00DC016644 · NIDCD · CORNELL UNIVERSITY · PI YANG, RONG · 2019 to 2021
$734k
NIDCD NIH HHS R00 DC016644NIDCD NIH HHS R01 DC015050NIDCD NIH HHS R01 DC015824
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antibioticotitis mediapermeabilitypermeability enhancerstemporal bonetympanic membrane

Identifiers

PMID33708167
PMCPMC7940379
OpenAlexW3130767265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.