Evidence map›Paper›PMID 33708074›Full record

ArticleFrontiers in cellular neuroscience2021

High-Intensity Exercise Training Protects the Brain Against Autoimmune Neuroinflammation: Regulation of Microglial Redox and Pro-inflammatory Functions.

Yifat Zaychik, Nina Fainstein, Olga Touloumi, Yehuda Goldberg, Liel Hamdi, Shir Segal, Hanan Nabat, Sofia Zoidou, Nikolaos Grigoriadis, Abram Katz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

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  9. [Mechanisms of spinal microglia and astrocytes in exercise-induced analgesia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  10. Oxidative Stress in Brain Function.Antioxidants (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Yifat ZaychikDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Nina FainsteinDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Olga TouloumiB' Department of Neurology, AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece.
Yehuda GoldbergDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Liel HamdiDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Shir SegalDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Hanan NabatDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Sofia ZoidouB' Department of Neurology, AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece.
Nikolaos GrigoriadisB' Department of Neurology, AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece.
Abram KatzÅstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden.
Tamir Ben-HurDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Ofira EinsteinDepartment of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Ariel University · ILAHEPA University Hospital · GRHadassah Medical Center · ILSwedish School of Sport and Health Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

autoimmunityexercise trainingexperimental autoimmune encephalomyelitismicrogliamultiple sclerosisneuroprotection

Identifiers

PMID33708074
PMCPMC7940666
OpenAlexW3110670425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.