Evidence map›Paper›PMID 33708036›Full record

ArticleAdvanced functional materials2021

Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity.

L Davenport Huyer, S Mandla, Y Wang, S Campbell, B Yee, C Euler, B F Lai, D Bannerman, D S Y Lin, M Montgomery and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Microparticles synthesized from itaconate polyesters enable metabolite delivery and elicit immunoregulatory outcomes.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  2. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Revisiting applications of itaconic acid-based polymers obtained by (poly)condensation chemistry.Green chemistry : an international journal and green chemistry resource : GC · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

L Davenport HuyerDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
S MandlaInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Y WangDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
S CampbellInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
B YeeDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
C EulerDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
B F LaiInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
D BannermanDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
D S Y LinInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
M MontgomeryDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
K NemrDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
T BenderDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
S EpelmanToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
R MahadevanDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
M RadisicDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
University Health Network · CAUniversity of Toronto · CA

Funding

Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
NHLBI NIH HHS R01 HL076485
6 · The paper itself

Abstract

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. We developed a library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers resulted in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibited bacterial growth on acetate. Translation to an

Identifiers

PMID33708036
PMCPMC7942808
OpenAlexW3102304184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.