Evidence map›Paper›PMID 33708032›Full record

ArticleAdvanced functional materials2020

Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation.

Jiayingzi Wu, Yifan Zhu, Liyan You, Pu-Ting Dong, Jianguo Mei, Ji-Xin Cheng

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiayingzi WuDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Yifan ZhuDepartment of Chemistry, Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.
Liyan YouDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Pu-Ting DongDepartment of Chemistry, Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.
Jianguo MeiDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Ji-Xin ChengDepartment of Chemistry, Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA; Department of Physics, Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Boston University · USPurdue University West Lafayette · US

Funding

Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
NIAID NIH HHS R01 AI141439
6 · The paper itself

Abstract

The electrochromism of a water-soluble naturally oxidized electrochromic polymer, ox-PPE, is harnessed for rapid and facile bacterial detection, discrimination, and susceptibility testing. The ox-PPE solution shows distinct colorimetric and spectroscopic changes within 30 min when mixed with live bacteria. For the underlying mechanism, it is found that ox-PPE responds to the reducing species (e.g. cysteine and glutathione) released by metabolically active bacteria. This reduction reaction is ubiquitous among various bacterial strains, with a noticeable difference that enables discrimination of Gram-negative and Gram-positive bacterial strains. Combining ox-PPE with antibiotics, methicillin-susceptible and -resistant

Indexed as

bacterial detectionelectrochromic polymerredox reactionsusceptibility evaluationthiols

Identifiers

PMID33708032
PMCPMC7941207
OpenAlexW3085392574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.