ArticleNature plants2021
Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 176 citations in OpenAlex.
- Engineering plant tandem kinase immune receptors expands effector recognition profiles.Science advances · 2026Article
- Identification of candidate gene for the wheat powdery mildew resistance gene Pm40 by bulked segregant analysis coupled with whole-genome sequencing (BSA-seq).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector.Nature communications · 2026Article
- k-mer-based approaches to unlock genebank genomics for targeted crop improvement.Nature genetics · 2026Review
- WheatRPred: deep learning framework for predicting disease resistance protein in wheat and its wild relatives.Journal, genetic engineering & biotechnology · 2026Article
- Bulked segregant RNA sequencing and linkage mapping identify a Pm4 allele conferring stable powdery mildew resistance in wheat breeding line YZ16.BMC plant biology · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Fine mapping of a powdery mildew resistance gene PmCWI16926 from cultivated emmer wheat.Communications biology · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Pm37 as a susceptible Sr22 allele confers resistance to wheat powdery mildew and leaf rust.Nature communications · 2026Article
- Fine mapping and transferring wheat adult-plant powdery mildew resistance gene Pm62 through T2DS·2VL translocations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors.Nature plants · 2026Article
- Population-scale gene expression analysis reveals the contribution of expression diversity to the modern wheat improvement.Nature communications · 2025Article
- Alternative splicing in plant stress responses: potential application for crop improvement.Planta · 2025Review
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Genetic Basis Identification of aPlants (Basel, Switzerland) · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 5 institutions in 6 countries.
Funding
Abstract
Crop breeding for resistance to pathogens largely relies on genes encoding receptors that confer race-specific immunity. Here, we report the identification of the wheat Pm4 race-specific resistance gene to powdery mildew. Pm4 encodes a putative chimeric protein of a serine/threonine kinase and multiple C2 domains and transmembrane regions, a unique domain architecture among known resistance proteins. Pm4 undergoes constitutive alternative splicing, generating two isoforms with different protein domain topologies that are both essential for resistance function. Both isoforms interact and localize to the endoplasmatic reticulum when co-expressed. Pm4 reveals additional diversity of immune receptor architecture to be explored for breeding and suggests an endoplasmatic reticulum-based molecular mechanism of Pm4-mediated race-specific resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.