ArticleScientific reports2021
Atrial high‑rate episodes and risk of major adverse cardiovascular events in patients with dual chamber permanent pacemakers: a retrospective study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sex-Specific Health and Economic Benefits in Older Women at Risk of Atrial Fibrillation: A Proof-of-Concept Evaluation of an AI-Enabled Strategy for Early Thromboembolic Risk Detection.Journal of clinical medicine · 2026Article
- Predictors for Device-Detected Subclinical Atrial Fibrillation: An Up-to-Date Narrative Review.Journal of clinical medicine · 2026Review
- Short-term effect of low atrial septum pacing on new-onset atrial fibrillation in patients with sinus node dysfunction a prospective randomized single-center study.Annals of medicine and surgery (2012) · 2025Article
- Mid-term comparison of new-onset AHRE between His bundle and left bundle branch area pacing in patients with AV block.Journal of arrhythmia · 2025Article
- CaMKIIδ-dependent dysregulation of atrial NaFrontiers in pharmacology · 2024Article
- Oral Anticoagulation in Patients With Atrial High-Rate Episodes: Focus on Clinical Implications.Cureus · 2023Article
- How should I treat patients with subclinical atrial fibrillation and atrial high-rate episodes? Current evidence and clinical importance.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Review
- The Differential Prognostic Impact of Long-Duration Atrial High-Rate Episodes Detected by Cardiac Implantable Electronic Devices between Patients with and without a History of Atrial Fibrillation.Journal of clinical medicine · 2022Article
- Atrial high-rate episodes predict major adverse cardio/cerebrovascular events in patients with cardiac implantable electrical devices.Scientific reports · 2021Observational
- HATCH Score and Left Atrial Size Predict Atrial High-Rate Episodes in Patients With Cardiac Implantable Electronic Devices.Frontiers in cardiovascular medicine · 2021Article
- Echocardiographic Parameters of Atrial High-rate Episodes in Patients with Cardiac Implantable Electronic Devices.Journal of cardiovascular echographyArticle
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2 authors.
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Abstract
Patients with atrial high-rate episodes (AHRE) are at higher risk of major adverse cardiovascular events (MACE). The cutoff threshold for AHRE duration for MACE, with/without history of atrial fibrillation (AF) or myocardial infarction (MI), is unknown. A total of 481 consecutive patients with/without history of AF or MI receiving dual-chamber pacemaker implantation were included. The primary outcome was a composite endpoint of MACE after AHRE ≥ 5 min, ≥ 6 h, and ≥ 24 h. AHRE was defined as > 175 bpm (MEDTRONIC) or > 200 bpm (BIOTRONIK) lasting ≥ 5 min. Cox regression analysis with time-dependent covariates was conducted. Patients' mean age was 75.3 ± 10.7 years and 188 (39.1%) developed AHRE ≥ 5 min, 115 (23.9%) ≥ 6 h, and 83 (17.3%) ≥ 24 h. During follow-up (median 39.9 ± 29.8 months), 92 MACE occurred (IR 5.749%/year, 95% CI 3.88-5.85). AHRE ≥ 5 min (HR 5.252, 95% CI 2.575-10.715, P < 0.001) and ≥ 6 h (HR 2.548, 95% CI 1.284-5.058, P = 0.007) was independently associated with MACE, but not AHRE ≥ 24 h. Patients with history of MI (IR 17.80%/year) had higher MACE incidence than those without (IR 3.77%/year, p = 0.001). Significant differences were found between MACE patients with/without history of AF in AHRE ≥ 5 min but not AHRE ≥ 6 h or ≥ 24 h. Patients with dual-chamber pacemakers who develop AHRE have increased risk of MACE, particularly after history of AF or MI.
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