Evidence map›Paper›PMID 33707587›Full record

ArticleScientific reports2021

MicroRNA-205-5p inhibits skin cancer cell proliferation and increase drug sensitivity by targeting TNFAIP8.

Xinhong Ge, Suryakant Niture, Minghui Lin, Patrice Cagle, P Andy Li, Deepak Kumar

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. microRNA-205 in prostate cancer: Overview to clinical translation.Biochimica et biophysica acta. Reviews on cancer · 2022
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xinhong Ge *Department of Dermatology, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
Suryakant Niture *Julius L. Chambers Biomedical Biotechnology Research Institute (BBRI), North Carolina Central University, 1801 Fayetteville St., Durham, NC, 27707, USA. sniture@nccu.edu.
Minghui LinDepartment of Respiratory Diseases, The Forth People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, 750021, Ningxia Hui Autonomous Region, China.
Patrice CagleJulius L. Chambers Biomedical Biotechnology Research Institute (BBRI), North Carolina Central University, 1801 Fayetteville St., Durham, NC, 27707, USA.
P Andy LiDepartment of Pharmaceutical Sciences, Bio-Manufacturing Research Institute and Technology Enterprise (BRITE), College of Health and Sciences, North Carolina Central University, Durham, NC, 27707, USA.
Deepak KumarJulius L. Chambers Biomedical Biotechnology Research Institute (BBRI), North Carolina Central University, 1801 Fayetteville St., Durham, NC, 27707, USA. dkumar@nccu.edu.
North Carolina Central University · USThe Fourth People's Hospital of Ningxia Hui Autonomous Region · CN

Funding

Understanding Perceptions of HIV Risk, PrEP, and PrEP use among African American Women Attending an HBCUU54MD012392 · NIMHD · NORTH CAROLINA CENTRAL UNIVERSITY · PI Seronda A Robinson · 2017 to 2026
$38.1M
Molecular Determinants of Social Factors in Prostate CancerR01MD012767 · NIMHD · NORTH CAROLINA CENTRAL UNIVERSITY · PI KUMAR, DEEPAK · 2017 to 2021
$5.7M
MicroRNAs in African American Prostate CancerU01CA194730 · NCI · UNIVERSITY OF THE DISTRICT OF COLUMBIA · PI KUMAR, DEEPAK · 2015 to 2020
$1.8M
NCI NIH HHS U01 CA194730NIMHD NIH HHS R01 MD012767NIMHD NIH HHS U54 MD012392
6 · The paper itself

Abstract

Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which regulates tumor growth and survival. Our goal is to delineate the detailed oncogenic role of TNFAIP8 in skin cancer development and progression. Here we demonstrated that higher expression of TNFAIP8 is associated with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma development in patient tissues. Induction of TNFAIP8 expression by TNFα or by ectopic expression of TNFAIP8 in SCC or melanoma cell lines resulted in increased cell growth/proliferation. Conversely, silencing of TNFAIP8 decreased cell survival/cell migration in skin cancer cells. We also showed that miR-205-5p targets the 3'UTR of TNFAIP8 and inhibits TNFAIP8 expression. Moreover, miR-205-5p downregulates TNFAIP8 mediated cellular autophagy, increased sensitivity towards the B-RAF

Indexed as

3' Untranslated RegionsAntineoplastic AgentsApoptosis Regulatory ProteinsAutophagyBase SequenceCell Line, TumorCell MovementCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHumansMicroRNAsSkin NeoplasmsTumor Necrosis Factor-alphaTumor Stem Cell AssayUp-Regulation3' Untranslated RegionsAntineoplastic AgentsApoptosis Regulatory ProteinsMicroRNAsMIR205, humanTNFAIP8 protein, humanTumor Necrosis Factor-alphaVemurafenib

Identifiers

PMID33707587
PMCPMC7952414
OpenAlexW3134337570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.