Observational studyScientific reports2021
Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Differences in clinical characteristics between coronavirus disease 2019 (COVID-19) and influenza: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2025Pooled it
- Hospitalised versus outpatient COVID-19 patients' background characteristics and comorbidities: A systematic review and meta-analysis.Reviews in medical virology · 2022Pooled it
- Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.Critical care medicine · 2021Pooled it
- Epidemiology of SARS-CoV-2, Influenza, RSV, and Human Metapneumovirus Across the COVID-19 Era: An Eight-Year Tertiary-Center Study in Saudi Arabia.Pathogens (Basel, Switzerland) · 2026Observational
- Global prevalence and determinants of hospital-acquired COVID-19: protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Comparative clinical and epidemiological characteristics of influenza and COVID-19 in hospitalized pediatric patients in Romania during and after the SARS-CoV-2 pandemic.Journal of medicine and life · 2026Observational
- Demystifying Quality Metrics and Unveiling the True Measure of Quality of Care in Nursing Homes: Mixed Effects Analysis.JMIR human factors · 2026Article
- CT Radiomics for the Early Identification of Fungal Co-infection in Immunocompromised Patients with Viral PneumoniaCurrent medical imaging · 2026Article
- Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database.JMIR medical informatics · 2025Article
- Detection of SARS-CoV-2 in nasopharyngeal swab samples from COVID-19 patients in Riyadh, Saudi Arabia: a PCR-based study.Virology journal · 2025Article
- Article
- Patient-Reported Outcomes in COVID-19 Treatment with Monoclonal Antibodies Reveal Benefits in Return to Usual Activities.Infectious diseases and therapy · 2024Article
- Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea.Journal of Korean medical science · 2024Article
- Lung adenocarcinoma discovered during the follow-up of lung-dominant connective tissue disease: a case report and literature review.BMC pulmonary medicine · 2024Review
- Comparative Clinical Assessment and Risk Stratification of COVID-19 and Influenza Infections in Adults and Children: A Comprehensive Systematic Review and Meta-Analysis.Bulletin of emergency and trauma · 2024Review
- Comparison of the clinical features and outcomes of severe seasonal influenza and COVID-19 patients in Tunisia between 2021 and 2022.Influenza and other respiratory viruses · 2023Article
- Comparing postacute care healthcare charges after hospitalisation due to influenza or COVID-19 infection in an all-payer administrative dataset in the USA: a retrospective cohort study.BMJ public health · 2023Article
- Article
- Assessing and Reassessing the Association of Comorbidities and Coinfections in COVID-19 Patients.Cureus · 2023Review
- Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study.Microbiology spectrum · 2023Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with COVID-19 diagnosed between February 27 and June 14, 2020, and 255 patients with seasonal influenza diagnosed during the 2017-18 season at the same hospital to describe common features and differences in clinical characteristics and course of disease. Patients with COVID-19 were younger (median age [IQR], 59 [45-71] vs 66 [52-77]; P < 0001) and had fewer comorbidities at baseline with a lower mean overall age-adjusted Charlson Comorbidity Index (mean [SD], 3.0 [2.6] vs 4.0 [2.7]; P < 0.001) than patients with seasonal influenza. COVID-19 patients had a longer duration of hospitalization (mean [SD], 25.9 days [26.6 days] vs 17.2 days [21.0 days]; P = 0.002), a more frequent need for oxygen therapy (101 [60.8%] vs 103 [40.4%]; P < 0.001) and invasive ventilation (52 [31.3%] vs 32 [12.5%]; P < 0.001) and were more frequently admitted to the intensive care unit (70 [42.2%] vs 51 [20.0%]; P < 0.001) than seasonal influenza patients. Among immunocompromised patients, those in the COVID-19 group had a higher hospital mortality compared to those in the seasonal influenza group (13 [33.3%] vs 8 [11.6%], P = 0.01). In conclusion, we show that COVID-19 patients were younger and had fewer baseline comorbidities than seasonal influenza patients but were at increased risk for severe illness. The high mortality observed in immunocompromised COVID-19 patients emphasizes the importance of protecting these patient groups from SARS-CoV-2 infection.
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