ArticleScientific reports2021
First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Atlantic to Pacific: Outbreak of bivalve transmissible neoplasia detected in hybridizing soft-shell clams and eDNA in Puget Sound.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Harmonized nonhuman cancer database.bioRxiv : the preprint server for biology · 2025Article
- Variation in natural infection outcomes and cancer cell release from soft-shell clams (Mya arenaria) with bivalve transmissible neoplasia.PLoS pathogens · 2025Article
- Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer.PLoS genetics · 2025Article
- Identification of an Outbreak of Bivalve Transmissible Neoplasia in Soft-Shell Clams (bioRxiv : the preprint server for biology · 2024Article
- Marine transmissible cancer navigates urbanized waters, threatening spillover.Proceedings. Biological sciences · 2024Article
- Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.Nature cancer · 2023Article
- Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians.Open biology · 2023Article
- Two lineages of bivalve transmissible neoplasia affect the blue musselCurrent zoology · 2023Article
- Population genetics of clonally transmissible cancers.Nature ecology & evolution · 2022Review
- Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea.Molecular ecology · 2022Article
- Survival and Detection of Bivalve Transmissible Neoplasia from the Soft-Shell ClamPathogens (Basel, Switzerland) · 2022Article
- Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the "Perfect Storm" Theory.Pathogens (Basel, Switzerland) · 2022Article
- Prevalence and polymorphism of a mussel transmissible cancer in Europe.Molecular ecology · 2022Article
- Traits of a mussel transmissible cancer are reminiscent of a parasitic life style.Scientific reports · 2021Article
- Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves.Non-coding RNA · 2021Article
- On the need for integrating cancer into the One Health perspective.Evolutionary applications · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.
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